Changes of ground substance in the inner ear in Alloxan diabetic mice
- 18 Downloads
One of the important substances in the ground substance is acidic glycosaminoglycans (AGAGs). Changes of AGAGs in the inner ear and in other organs were investigated using alloxan diabetic mice in order to contribute to the understanding of diabetic hearing impairment. In the diabetic group, gradual increases of AGAGs were observed in each tissue. On the 60th day after alloxan injection, AGAG values were increased 3.5-fold in the cochlea, 2.5-fold in the brain, 13-fold in the liver, twofold in the kidney, and fivefold in the pancreas compared with the control values. It is interesting to note that both the cochlea and pancreas showed continuous increases of AGAGs.
Key wordsDiabetic hearing impairment Alloxan diabetes Acidic glycosaminoglycans
Unable to display preview. Download preview PDF.
- Berenson GS, Ruiz H, Dalferes ER, Dugan FA, Radhakrischnamurthy B (1970) Acid mucopolysaccharide changes in diabetic kidneys. Diabetes 19: 161–170Google Scholar
- Cohen MP, Foglia VG (1971) The effect of diabetes on the metabolism of mucopolysaccharides. Acta Diabetol Lab 8: 1079–1089Google Scholar
- Costa OA (1967) Inner ear pathology in experimental diabetes. Laryngoscope 77: 68–75Google Scholar
- Garcia-Quiroga J, Norris CH, Glade L, Bryant GM, Tachibana M, Guth PS (1978) The relationship between kanamycin ototoxicity and glucose transport. Res Commun Chem Pathol Pharmacol 22: 535–547Google Scholar
- Jorgensen MB (1961) The inner ear in diabetes mellitus. Arch Otolaryngol 74: 373–381Google Scholar
- Kovar M (1973) The inner ear in diabetes mellitus. ORL 35: 42–51Google Scholar
- Meyer K, Davidson E, Linker A, Huffman P (1956) The acid mucopolysaccharides of connective tissue. Biochem Biophys Acta 21: 506–518Google Scholar
- Oliveira CA, Kruse C, Juhn SK (1977) Cochlear vascular changes in streptozotocin diabetes in chinchillas. Trans Am Acad Ophthalmol Otolaryngol 84: 443–451Google Scholar
- Schacht J (1976) Biochemistry of neomycin ototoxicity. J Acoust Soc Am 59: 940–944Google Scholar
- Saito H, Daly JF (1971) Quantitative analysis of acid mucopolysaccharides in normal and kanamycin intoxicated cochlea. Acta Otolaryngol (Stockh.) 71: 22–26Google Scholar
- Schiller S, Dorfman A (1957) The metabolism of mucopolysaccharides in animals. IV. The influence of insulin. J Biol Chem 227: 625–632Google Scholar