Archives of oto-rhino-laryngology

, Volume 239, Issue 1, pp 41–47 | Cite as

Changes in the stria vascularis of the guinea pig due to cis-platinum

  • R. A. Tange
  • V. D. Vuzevski


The microscopical and ultramicroscopical changes in the stria vascularis due to cis-diamminedichloroplatinum II (DDP) were studied. Sixteen healthy adult guinea pigs were used for the experiment. A standard dosage DDP (1.5 mg/kg/d) was administered over a period of 5–20 days. A clear degeneration pattern was found (ranging from no changes to cystic degeneration with protrusion of marginal cells followed by loss of marginal cells). DDP seems to be especially toxic for marginal cells in stria vascularis in the guinea pig.

Key words

Cis-diamminedichloroplatinum II Guinea pig Stria vascularis Changes in marginal cells 


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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • R. A. Tange
    • 1
  • V. D. Vuzevski
    • 2
  1. 1.Dept. of OtorhinolaryngologyUniversity Hospital “Dijkzigt”GD RotterdamThe Netherlands
  2. 2.Dept. of PathologyUniversity Hospital “Dijkzigt”GD RotterdamThe Netherlands

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