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Double primary synchronous and metachronous cancer of the larynx and hypopharynx with dissimilar histology

Primäres Doppelkarzinom an Kehlkopf und Hypopharynx mit unterschiedlicher Histologie

Five case reports and review of the literature

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Archives of oto-rhino-laryngology Aims and scope Submit manuscript

Zusammenfassung

Bericht über fünf Fälle mit primärem Doppelkarzinom unterschiedlicher Histologie an Kehlkopf oder Hypopharynx. Bei vier Patienten waren ein Plattenepithelkarzinom und ein Oat-Zellkarzinom (kleinzelliges anaplastisches Karzinom) kombiniert. Im fünften Fall bestand neben einem Plattenepithelkarzinom ein malignes, fibröses Histiozytom. Die Pathogenese ist noch unklar.

Summary

Five cases of double primary synchronous and metachronous cancers of the larynx and hypopharynx with dissimilar histology encountered at the Section of Pathology of the Department of Otolaryngology of Padua University from 1966 through 1979 are reported. The pathogenesis of these double primary malignancies is discussed, and in particular stress is laid on the perhaps not purely coincidental association of squamous cell and oat cell carcinoma of the larynx and hypopharynx. Furthermore, a thorough review of the literature is made on the reported cases of two primary simultaneous or metachronous malignancies of the larynx and hypopharynx of different histological type.

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Authors and Affiliations

  1. Section of Pathology, Department of Otolaryngology, University of Padua, I-35100, Padua, Italy

    Alfio Ferlito

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  1. Alfio Ferlito
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This study was supported by the Consiglio Nazionale delle Ricerche. Grant No. C. T. 77.01338.04

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Ferlito, A. Double primary synchronous and metachronous cancer of the larynx and hypopharynx with dissimilar histology. Arch Otorhinolaryngol 229, 107–119 (1980). https://doi.org/10.1007/BF00454234

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  • DOI: https://doi.org/10.1007/BF00454234

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