Summary
Complications after preoperative high-dosage radiation of head and neck cancer are reported:
-
1.
Preoperative radiation leads to complications in 42% compared to surgery alone in 20%. The results are statistically significant (α=2%).
-
2.
The complications after preoperative radiation are more severe (three ruptures of the carotid artery, three defects, which could only be managed by flap rotation).
These results indicate that preoperative high-dosage radiation implies the risk of major surgical complications.
Zusammenfassung
In einer retrospektiven Studie werden die postoperativen Heilverläufe von 55 primär mit voller Tumordosis bestrahlten mit einer gleich großen Gruppe primär operierter Patienten verglichen. Dabei fanden sich folgende Ergebnisse:
-
1.
Bei den zuvor bestrahlten Patienten war die Komplikationsrate mit 42% gegenüber 20% bei den primär operierten signifikant (α=2%) höher.
-
2.
Nach Bestrahlung nimmt die Schwere der Komplikationen erheblich zu (drei Carotisblutungen; drei Defekte, die nur durch langwierige plastische Maßnahmen zu decken waren).
Similar content being viewed by others
Literatur
Anderson WAD (1966) Pathology, 5th edn. CV Mosby, St. Louis
Bozzi E, Cova PL, Botti G, Tosi G (1966) Surgery possibilities for laryngeal and hypopharyngeal carcinoma after treatment with high-energy betatron electrons. Acta Otolaryngol 62: 44
Cachin Y, Richard J, Lalanne C (1965) Chirurgie du larynx et de l'hypopharynx après radiothérapie. Rev Laryngol Otol Rhinol 86: 370
Cachin Y, Eschwege F (1975) Combination of radiotherapie and surgery in the treatment of head and neck cancers. Cancer Treat Rev 2: 171
Cachin Y, Vandenbrouk C (1975) In: Problèmes Actuels d'ORL. Maloine Editeur (Presse), Paris
Chung CT, Sagerman RH, King GA, Yu WS, Johnson JG, Cummings CW (1978) Complications of high dose preoperative irradiation for advanced laryngeal-hypopharyngeal cancer. Radiology 128: 467
Goldman JL, Silverstone SM, Roffman JD, Birken EA (1972) High-dosage pre-operative radiation and surgery for carcinoma of the larynx and laryngopharynx — a 14-years program. Laryngoscope 82: 1869
Goldman JL, Roffman JD (1975) Combined pre-operative irradiation and surgery for advanced cancer of the larynx and laryngopharynx. Can J Otolaryngol 4: 251
Joseph D, Shumrick D (1973) Risks of head and neck surgery in previously irradiated patients. Arch Otolaryngol 97: 381
Kambič V, Sirca A (1977) H-incision-method of choice for radical neck dissection. J Laryngol Otol 91: 383
Kaufmann H, Lichtenberger K (1967) Erfahrungen mit der Telegamma-Therapie der Larynx- und Hypopharynxcarcinome. HNO 15: 161
Ketcham AS, Hoyce RC, Chretien PB, Brace KC (1969) Irradiation twenty-four hours preoperatively. Am J Surg 118: 691
Lawrence W jr, Terz JJ, Rogers C, King RE, Wolf JS, King ER (1974) Proceedings: Preoperative irradiation for head and neck cancer: a prospective study. Cancer 33: 318
Levitt SH, Beachley MC, Zimberg Y, Pastore PN, De Giorgi LS, King ER (1971) Combination of preoperative irradiation and surgery in the treatment of cancer of the oropharynx, hypopharynx, and larynx. Cancer 27: 759
Shumrick DA (1973) Carotid artery rupture. Laryngoscope 83: 1051
Stell PM, Cooney TC (1974) Management of fistulae of head and neck after radical surgery. J Laryngol Otol 88: 819
Trible WM (1957) The effect of preoperative radiation on subsequent surgery in carcinoma of the larynx. Ann Otol Rhinol Laryngol 66: 953
Van den Bergh HJ jr, Chen SC, Blatt CJ, Berkas EM (1965) A comparison of wound healing between irradiated and nonirradiated patients after radical neck dissection. Am J Surg 110: 557
Vandenbrouk C, Sancho H, Le Fur R, Richard JM, Cachin Y (1977) Results of a randomized clinical trial of preoperative irradiation versus postoperative in treatment of tumors of the hypopharynx. Cancer 39: 1445
Yarrington CT, Yonkers AJ, Beddoe GM (1976) Avoiding complications in radical neck dissection. Laryngoscope 86: 325
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Laniado, K., Schumann, K. & Silber, T. Komplikationen nach Tumoroperationen im HNO-Bereich. Arch Otorhinolaryngol 229, 99–105 (1980). https://doi.org/10.1007/BF00454233
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00454233