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Studie zur intraarteriellen Mono- und Polychemotherapie von Mundhöhlen- und Oropharynxkarzinomen: Methotrexat (MTX) im Vergleich zur Kombination Vincristin-Methotrexat-Bleomycin-Cisplatin (VMBP)

A comparative study between intraarterial cytostatic monotherapy and polytherapy in cases with carcinomas of the oropharynx and the oral cavity: Methotrexat versus a combination of Vincristin, Methotrexat, Bleomycin, and Cisplatin (VMBP)

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Summary

A comparative study was performed on intraarterial cystotatic monotherapy with Methotrexat (MTX) and polychemotherapy with Vincristin-MTX-Bleomycin-Cisplatin (VMBP). The polychemotherapy proved to be superior to the monotherapy as demonstrated by the remission rate of the tumors.

Only 3 of 21 patients treated with MTX alone showed a partial remission. In comparison, patients who received polychemotherapy showed in ten cases a complete and in seven cases a partial remission. The series contained 21 patients. Both groups of patients were comparable in localization and extent of the tumors and in nodal involvement. The aim of the initial chemotherapy was to reduce the tumor growth before surgery.

Zusammenfassung

In einer vergleichenden Studie wurde bei Karzinomen der Mundhöhle und des Oropharynx der zytostatische Effekt einer intraarteriellen Monotherapie mit Methotrexat (MTX) einer Polychemotherapie mit Vincristin-Methotrexat-Bleomycin-Cisplatin (VMBP) gegenübergestellt.

Es erwies sich die Viererkombination – VMBP – der Monotherapie mit MTX, gemessen an der Zahl der Remissionsraten, überlegen. Unter Methotrexat erreichten drei von 21 Patienten eine partielle Remission, gegenüber zehn kompletten und sieben partiellen Remissionen bei der Polychemotherapie. Die untersuchten Kollektive waren in Patientenzahl, Tumorlokalisation, Ausdehnung und lokaler Metastasierung vergleichbar. Ziel der initialen Chemotherapie war es eine praeoperative Reduktion der Tumormasse zu erreichen. Regelmäßig wurde nach der Zytostatikatherapie operiert und bestrahlt.

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  1. Hals-, Nasen-, Ohrenklinik und Poliklinik Klinikum der Johannes Gutenberg-Universität, Langenbeckstraße 1, D-6500, Mainz, Bundesrepublik Deutschland

    H. Mika

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Mika, H. Studie zur intraarteriellen Mono- und Polychemotherapie von Mundhöhlen- und Oropharynxkarzinomen: Methotrexat (MTX) im Vergleich zur Kombination Vincristin-Methotrexat-Bleomycin-Cisplatin (VMBP). Arch Otorhinolaryngol 237, 59–65 (1982). https://doi.org/10.1007/BF00453718

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  • DOI: https://doi.org/10.1007/BF00453718

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