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The cortitoxic effects of cis-platinum in the guinea pig

Der ototoxische Effekt von Cis-Platin beim Meerschweinchen

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Zusammenfassung

Untersuchung der Cis-Platin-Wirkung auf das Cortische Organ des Meerschweinchens mittels Zytocochleogramm und Elektronenmikroskopie. Die Schädigung begann stets an den äußeren Haarzellen der Basalwindung. Der Beginn der Degeneration konnte nicht exakt bestimmt werden. Tiere mit Hörverlust zeigten einen Verlust des Körpergewichtes. Vielleicht trägt der letztere zur Verstärkung des ototoxischen Effektes bei.

Summary

Cis-diammine-dichloroplatinum-II (DDP)-induced cochlear degeneration in the guinea pig was studied by complete hair-cell counting (cytocochleograms) and transmission electron microscopy. The DDP (1.5 mg/kg/day) was administrated over a period of 5–20 days. The degeneration of the organ of Corti started sporadically in almost every outer hair-cell (OHC) with a strong prevelance in the OHC 1 in the basal turn.

No distinct starting point for the degeneration of the organ of Corti could be found. It seemed that the ototoxic effects of DDP are rather different from the ototoxic changes due to aminoglycoside antibiotics.

This study showed that the animals with hearing loss due to DDP also had a clear loss of body weight. Perhaps DDP induces toxic effects (loss of body weight) which can amplify the ototoxic effects.

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Authors and Affiliations

  1. Dept. of Otorhinolaryngology, University Hospital “Dijkzigt”, Dr. Molewaterplein 40, NL-3015, GD Rotterdam, The Netherlands

    R. A. Tange MD, E. A. J. G. Conijn & L. G. P. M. van Zeijl

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  1. R. A. Tange MD
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  2. E. A. J. G. Conijn
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  3. L. G. P. M. van Zeijl
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Supported by grants from the Heinsius Houbolt Foundation

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Tange, R.A., Conijn, E.A.J.G. & van Zeijl, L.G.P.M. The cortitoxic effects of cis-platinum in the guinea pig. Arch Otorhinolaryngol 237, 17–26 (1982). https://doi.org/10.1007/BF00453712

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  • DOI: https://doi.org/10.1007/BF00453712

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