Summary
Acidic glycosaminoglycans in the ground substance of the membranous cochlear lateral wall, kidney, brain and liver of the guinea pigs were quantitatively and qualitatively analyzed, using electrophoretic microanalysis. The lateral wall of the cochlea showed highest content (0.46±0.08%/D.W.) of acidic glycosmainoglycans, which were chondroitin sulfate-B (75%), chondroitin sulfate-A (12%) and hyaluronic acid (13%). However, the pattern of these acidic glycosaminoglycans in the inner ear differed from the other organs. A possible role of acidic glycosaminoglycans in the inner ear was discussed.
Zusammenfassung
Die quantitative und qualitative Analysen der sauren Glykosaminoglykane in den Grundsubstanzen der lateralen Wand des häutigen Labyrinths, der Nieren, des Gehirns und der Leber von Meerschweinchen wurden mittels der elektrophoretischen Mikroanalysenmethode ausgeführt. Die laterale Wand der Schnecke enthielt die höchste Menge (0,46±0,08% pro Trockengewicht) der sauren Glykosaminoglykane, die aus Chondroitinsulfat-B (75%), Chondroitinsulfat-A (12%) und Hyaluronsäure (13%) bestanden. Jedoch schwankt die Zusammensetzung der Glykosaminoglykane im Innenohr, ebenso wie in den anderen Organen, erheblich. Eine mögliche Bedeutung der Glykosaminoglykane für die Funktion des Hörorgans wurde diskutiert.
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Saito, H., Nakamura, A. & Iida, T. A comparison of acidic glycosaminoglycans in the inner ear and other organs: Electrophoretic microanalysis. Arch Otorhinolaryngol 214, 149–155 (1976). https://doi.org/10.1007/BF00453611
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DOI: https://doi.org/10.1007/BF00453611