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Effects of irradiation on the ciliary activity of the eustachian tube and the middle ear mucosa

Archives of oto-rhino-laryngology volume 242, pages 343–348 (1985)Cite this article

Summary

Radiation-induced changes in the ciliary activity of the eustachian tube and middle ear mucosa were investigated in a laboratory model. Twenty-four guinea pigs were sacrificed, and a mucosa at the bony portion of each eustachian tube and from the middle ear proximal and distal to the tube were sampled. The mucosal samples were irradiated with 200 kV hard X-rays discretely at a dosage level of 0.5–30.0 Gy, and the induced changes in ciliary activity were expressed as a percent deviation from baseline levels before irradiation. The present study demonstrates that the cilia of the eustachian tube and middle ear mucosa show different reactions to irradiation according to their tympanic locations.

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References

  1. Baldetorp L, Håkansson CH (1977) Response of ciliated cells during irradiation at different dose rates. Acta Radiol Ther Phys Biol 16:378–384

    Google Scholar 

  2. Bremond G, Coquin A (1972) Ultrastructure of normal and pathological middle ear mucosa. J Laryngol 86:457–472

    Google Scholar 

  3. Fujiwara K, Håkansson CH, Toremalm NG (1972) Influence of ionizing radiation on ciliary cell activity in the respiratory tract. Acta Radiol Ther Phys Biol 11:513–519

    Google Scholar 

  4. Harada Y (1977) Scanning electron microscopic study on the distribution of epithelial cells in eustachian tube. Acta Otolaryngol (Stockh) 83:284–290

    Google Scholar 

  5. Hentzer E (1984) Ultrastructure of the middle ear mucosa. Acta Otolaryngol [Suppl] (Stockh) 414:19–27

    Google Scholar 

  6. Ikeoka H, Ohashi Y, Maruoka K, Nakata J, Masutani H, Nakai Y, Horiguchi S, Teramoto K (1984) Effects of tetrahydrofuran exposure on the ciliary activity and morphology of tracheal epithelium in rabbits. Osaka City Med J 30:53–67

    Google Scholar 

  7. Kawabata I, Paparella MM (1969) Ultrastructure of normal human middle ear mucosa. Ann Otol Rhinol Laryngol 78:125–137

    Google Scholar 

  8. Kihara S, Ohashi Y, Maruoka K, Ikeoka H, Masutani H, Nakai Y (1985) The ciliary activity of the middle ear lining in some pathological states. Auris Nasus Larynx (in press)

  9. Lee W, Verdugo P (1976) Laser light-scattering scpectroscopy: a new application in the study of ciliary activity. Biophys J 16:1115–1119

    Google Scholar 

  10. Lim DJ, Klainer A (1971) Cellular reaction in acute otitis media: scanning and transmission electron microscopy. Laryngoscope 81:1772–1786

    Google Scholar 

  11. Lim DJ, Shimada T (1971) Secretory activity of normal middle ear, mastoid cavities, and eustachian tube. Ann Otol Rhinol Laryngol 78:125–137

    Google Scholar 

  12. Lim DJ, Paparella MM, Kimura RS (1967) Ultrastructure of the eustachian tube and middle ear mucosa in the guinea pigs. Acta Otolaryngol (Stockh) 63:425–444

    Google Scholar 

  13. Ohashi Y (1983) The function and morphology of respiratory ciliated cells. J Osaka City Med Cent 32:427–460

    Google Scholar 

  14. Ohashi Y, Nakai Y (1983) Functional and morphological studies on chronic sinusitis mucous membrane. 1. Reduced ciliary action in chronic sinusitis. Acta Otolaryngol [Suppl] (Stockh) 397:3–9

    Google Scholar 

  15. Ohashi Y, Nakai Y (1983) Functional and morphological studies on chronic sinusitis mucous membrane. 2. Functional and morphological pathology of chronic sinusitis mucous membrane. Acta Otolaryngol [Suppl] (Stockh) 397:11–48

    Google Scholar 

  16. Ohashi Y, Nakai Y (1984) Mucociliary activities in fetal rabbits. Acta Otolaryngol (Stockh) 97:351–358

    Google Scholar 

  17. Ohashi Y, Nakai Y, Nakata J, Ikeoka H, Maruoka K, Horiguchi S, Teramoto K (1983) Effects on the ciliary activity and morphology of rabbit's nasal epithelium exposed to tetrahydrofuran. Osaka City Med J 29:1–14

    Google Scholar 

  18. Ohashi Y, Nakai, Y Kihara S (1985) Ciliary activity of the middle ear lining in guinea pigs. Ann Otol Rhinol Laryngol (in press)

  19. Ohashi Y, Nakai Y, Kihara S, Maruoka K, Ikeoka H, Uemura Y (1985) The ciliary activity of the middle ear lining: functional and morphological observation. Auris Nasus Larynx (in press)

  20. Ohashi Y, Nakai Y, Kihara S, Ikeoka H, Takano H, Imoto T (1985) Ciliary activity in patients with nasal allergies. Arch Otorhinolaryngol (in press)

  21. Ohashi Y, Nakai Y, Ikeoka H, Maruoka K, Koshimo H (1985) Determination of the ciliary activity by the photo-electric method. J Jpn Bronchoesophagol Soc 36:69–78

    Google Scholar 

  22. Reimer Å (1978) The mucociliary activity of the upper respiratory tract. III. A functional and morphological study on human and animal with special reference to maxillary sinus disease. Acta Otolaryngol [Suppl] (Stockh) 355:1–20

    Google Scholar 

  23. Sadé J, Afula F (1967) Ciliary activity and middle ear clearance. Arch Otolaryngol 86:128–135

    Google Scholar 

  24. Sakakura Y (1973) Mucociliary function during experimentally induced rhinovirus infection in man. Ann Otol Rhinol Laryngol 82:103–211

    Google Scholar 

  25. Santa CR (1974) Tracheal mucous velocity in normal and patients with obstructive lung diseases; effects of terbutaline. Am Rev Resp Dis 109:458–463

    Google Scholar 

  26. Shimada T, Lim DJ (1972) Distribution of ciliated cells in the human middle ear; electron and light microscopic observation. Ann Otol Rhinol Laryngol 81:203–211

    Google Scholar 

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Affiliations

  1. Department of Otolaryngology, Osaka City University Medical School, Abeno-ku, 545, Osaka, Japan

    Yoshihiro Ohashi, Yoshiaki Nakai, Hiroshi Ikeoka & Hiroyuki Koshimo

  2. Department of Radiology, Osaka City University Medical School, Abeno-ku, 545, Osaka, Japan

    Yasuto Onoyama

Authors
  1. Yoshihiro Ohashi
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  2. Yoshiaki Nakai
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  3. Hiroshi Ikeoka
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  4. Hiroyuki Koshimo
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  5. Yasuto Onoyama
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Ohashi, Y., Nakai, Y., Ikeoka, H. et al. Effects of irradiation on the ciliary activity of the eustachian tube and the middle ear mucosa. Arch Otorhinolaryngol 242, 343–348 (1985). https://doi.org/10.1007/BF00453560

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  • DOI: https://doi.org/10.1007/BF00453560

Key words

  • Ciliary activity
  • Middle ear mucosa
  • Irradiation