Sclerotic changes around the endolymphatic sac in human temporal bones
- 14 Downloads
We used light microscopy to study 87 human temporal bones (from 47 cases) with no known otological disorders, and found that certain cases had sclerotic changes around the endolymphatic duct and sac. Changes included fibrosis, hyalinization, psammoma formation, and thickened vascular walls. The findings were subjected to statistical analysis, which indicated that most of the changes could be positively correlated with increases in age.
Key wordsHuman temporal bone Endolymphatic sac Sclerotic changes Aging Statistical analysis
Unable to display preview. Download preview PDF.
- 1.Altmann F, Zechner G (1968) The pathology and pathogenesis of endolymphatic hydrops. New investigations. Arch Ohren-Nasen-Kehlkopfheilkd 192:1–19Google Scholar
- 2.Dunn J jr, Kernohan JW (1955) Histologic changes within the choroid plexus of the lateral ventricle. Their relation to age. Proc Mayo Clin 30:607–615Google Scholar
- 3.Fraysse BG, Alonso A, House WF (1980) Menière's disease and endolymphatic hydrops. Clinical-histopathological correlations. Ann Otol Rhinol Laryngol [Suppl 76] 89:2–22Google Scholar
- 4.Gussen R (1971) Tissue changes about the endolymphatic sac. Arch Otolaryngol 94:406–413Google Scholar
- 5.Gussen R (1974) Menière syndrome. Compensatory collateral venous drainage with endolymphatic sac fibrosis. Arch Otolaryngol 99:414–418Google Scholar
- 6.Hallpike CS, Cairns H (1938) Observations on the pathology of Menière's syndrome. J Laryngol Otol 53:625–654Google Scholar
- 7.Saito H, Kitahara M, Yazawa Y, Matsumoto M (1977) Histopathologic findings in surgical specimens of endolymphatic sac in Menière's disease. Acta Otolaryngol 83:465–469Google Scholar
- 8.Schindler RA (1979) The ultrastructure of the endolymphatic sac in Menière's disease. Adv Otorhinolaryngol 25:127–133Google Scholar
- 9.Schuangshoti S, Netsky MC (1970) Human choroid plexus. Morphologic and histochemical alterations with age. Am J Anat 128:73–96Google Scholar
- 10.Zechner G, Altmann F (1969) Histological studies on the human endolymphatic duct and sac. Pract Oto-Rhino-Laryngol 31:65–83Google Scholar