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Psychopharmacologia

, Volume 8, Issue 5, pp 309–318 | Cite as

On certain psychopharmacological and physiological differences between schizophrenic and normal persons

  • Conan Kornetsky
  • Allan F. Mirsky
Reviews

Summary

The schizophrenic patient is generally regarded to be less responsive than the normal person to many drugs as well as to certain nonpharmacological conditions. Evidence is presented that there is not an attenuated response in the schizophrenic with all centrally acting drugs. The schizophrenic may in fact be more responsive than the normal person to some nonpharmacological conditions. These studies are reviewed and a neuropsychological hypothesis proffered which may account for some of the differences between the normal and the schizophrenic.

The hypothesis states that the schizophrenic patients are in a state of chronic hyperarousal. This results from dysfunction in those areas of the brain concerned with the maintainence of arousal, and attention, i. e. the brain stem reticular activating system.

Keywords

Brain Stem Schizophrenic Patient Normal Person Physiological Difference Neuropsychological Hypothesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1965

Authors and Affiliations

  • Conan Kornetsky
    • 1
  • Allan F. Mirsky
    • 1
  1. 1.Department of Pharmacology and the Division of PsychiatryBoston University School of Medicine, Boston University Medical CenterBoston

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