Abstract
The Culex circadian pacemaker's response to phase-resetting light signals was studied in the first 3 cycles of darkness following a 12h light exposure. (1) In both cycles 1 and 2 there is a clear change from “type 1” to “type 0” phase-resetting as the resetting signal is prologed (Fig. 2). (2) Mosquitoes in cycle 1 are about half as sensitive to phase-resetting as those in cycles 2 or 3 (the criterion being the minimum pulse duration required to produce type 0 phase-resetting) (Fig. 2). (3) Each cycle appears to have a corkscrew-shaped phaseresetting surface and a phase singularity (Figs. 4, 5, and 7). The hypothesis that the Culex pacemaker reaches a stable limit cycle within the first cycle leads to an economical explanation of the results.
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References
Eskin, A.: Some properties of the system controlling the circadian activity rhythm in sparrows. In: Biochronmetry Menaker, M. (ed.), pp. 55–80. Washington, D.C.: National Academy of Sciences 1971
Jones, M.D.R.: Persistence in continuous light of a circadian rhythm in the mosquito Culex pipiens fatigans wied. Nature 261, 491–492 (1976)
Jones, M.D.R., Cubbin, C.M., Marsh, D.: The circadian rhythm of flight activity of the mosquito Anopheles gambiae: The light response rhythm. J. Exp. Biol. 57, 337–346 (1972)
Jones, M.D.R., Hill, M., Hope, A.M.: The circadian flight activity of the mosquito Anopheles gambiae: Phase setting by the light regime. J. Exp. Biol. 47, 503–511 (1967)
Pavlidis, T.: Studies on biological clocks: A model for the circadian rhythms of nocturnal organisms. In: Lectures on mathematics in the life sciences Gerstenhaber, M. (ed.), pp. 88–112. Providence R.I.: American Math. Soc. 1968
Pavlidis, T.: Biological oscillators: their mathematical analysis. New York: Academic Press 1973
Pavlidis, T.: Qualitative similarities between the behaviour of coupled oscillators and circadian rhythms. Bull. math. Biol. 40, 675–690 (1978)
Peterson, E.L.: The temporal pattern of mosquito flight activity. Behaviour 72, 1–25 (1980a)
Peterson, E.L.: A limit cycle interpretation of a mosquito circadian oscillator. J. theor. Biol. 84, 281–310 (1980b)
Peterson, E.L.: Phase-resetting a mosquito circadian oscillator. I. Phase-resetting surface. J. Comp. Physiol. 138, 201–211 (1980c)
Peterson, E.L.: Dynamic response of a circadian pacemaker. II. Recovery from light pulse perturbations. 40, 181–194 (1981)
Peterson, E.L., Jones, M.D.R.: Do circadian oscillators ever stop in constant light? Nature 230, 677–679 (1979)
Peterson, E.L., Saunders, D.S.: The circadian eclosion rhythm in Sarcophaga argyrostoma: A limit cycle representation of the pacemaker. J. theor. Biol. 86, 265–277 (1980)
Pittendrigh, C.S.: Circadian systems I. The driving oscillation and its assay in Drosophila pseudoobscura. Proc. Nat. Acad. Sci. (US) 58, 1762–1767 (1967)
Pittendrigh, C.S., Daan, S.: A functional analysis of circadian pacemakers in nocturnal rodents. I. The stability and lability of spontaneous frequency. J. Comp. Physiol. 106, 223–252 (1976)
Roberts, S.K. de F.: Circadian activity rhythms in cockroaches. I. The free-running rhythm in steady state. J. Cell. Comp. Physiol. 55, 99–110 (1960)
Saunders, D.S.: An experimental and theoretical analysis of photoperiodic induction in the flesh-fly Sarcophaga argyrostoma. J. Comp. Physiol. 124, 75–95 (1978)
Winfree, A.T.: An integrated view of the resetting of a circadian clock. J. theor. Biol. 27, 327–374 (1970)
Winfree, A.T.: On the photosensitivity of circadian time sense in Drosophila pseudoobscura. J. theor. Biol. 35, 159–189 (1972a)
Winfree, A.T.: Slow dark adaptation in Drosophila's circadian clock. J. Comp. Physiol. 77, 418–434 (1972b)
Winfree, A.T.: The investigation of oscillatory processes by perturbation experiments. In: Biological and biochemical oscillators. Chance, B., Pye, E.K., Hess, B. (eds.), pp. 461–501. New York: Academic Press 1973a
Winfree, A.T.: Resetting the amplitude of Drosophila's circadian chronometer. J. Comp. Physiol. 85, 105–114 (1973b)
Winfree, A.T.: On phase resetting in multicellular clockshops. In: The molecular basis of circadian rhythms. Hastings, J.W., Schweiger, H.-G. (eds.), pp. 109–129. Berlin: Dahlem Konferenzen 1976
Winfree, A.T., Gordon, T.: The photosensitivity of a mutant circadian clock. J. Comp. Physiol. 122, 87–109 (1977)
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Peterson, E.L. Dynamic response of a circadian pacemaker. Biol. Cybern. 40, 171–179 (1981). https://doi.org/10.1007/BF00453367
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DOI: https://doi.org/10.1007/BF00453367