Advertisement

Mycopathologia

, Volume 101, Issue 2, pp 105–111 | Cite as

Disseminated cutaneous and peritoneal hyalohyphomycosis caused by Fusarium species: Three cases and review of the literature

  • John W. Rippon
  • Richard A. Larson
  • Daniel M. Rosenthal
  • Joseph Clayman
Article

Abstract

Three recent cases of hyalohyphomycosis caused by Fusarium sp. illustrate differing aspects of infections produced by these organisms. One patient was undergoing continuous ambulatory peritoneal dialysis when peritonitis developed caused by Fusarium moniliforme. Removal of the catheter and amphotericin B were used in successful management. In a neutropenic patient on therapy for leukemia, multiple persistent infections occurred including JK diptheroids, and Candida albicans sepsis. Finally, numerous florid skin lesions caused by Fusarium oxysporum developed even while the patient was receiving amphotericin B and he died. In a second neutropenic patient on treatment for leukemia, sinus and cutaneous lesions developed due to Fusarium. These resolved on amphotericin B therapy following the return of circulating neutrophils. The literature on Fusarium infections and aspects of the biology of the organism are reviewed.

Keywords

Leukemia Candida Peritonitis Amphotericin Fusarium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Abramowski CR, Cuin D et al. Systemic infection by Fusarium in a burned child. J Pediatrics 1974; 84:561–564.Google Scholar
  2. 2.
    Ainsworth GC, Austwick, PKC. A survey of animal mycoses in Britain. Trans Br Mycol Soc 1955; 38:369–386.Google Scholar
  3. 3.
    Ajello L. Hyalohyphomycosis and phaeohyphomycosis: two global disease entities of public health importance. European J Epidermiology 1986; 2:243–251.Google Scholar
  4. 4.
    Anaissie E, Kantarjian H, Jones P, Barlogie B, Luna M, Lopez-Berestein G, Bodey GP. Fusarium. A newly recognized fungal pathogen in immunosuppressed patients. Cancer 1986; 57:2141–2145.Google Scholar
  5. 5.
    Arfania D, Everett ED, Nolph KD, Rubin J. Uncommon causes of peritonitis undergoing peritoneal dialysis. Arch Int Med 1981; 141:61–64.Google Scholar
  6. 6.
    Attapattu MC, Annadakrishman C. Extensive subcutaneous hyphomycosis caused by Fusarium oxysporum. Med Veterin Mycol 1986; 24:105–111.Google Scholar
  7. 7.
    Austwick PKC. Fusarium infections in human and animals. In Moss M, Smith JE, eds. The applied mycology of Fusarium. New York: Cambridge University Press, 1984; 129–140.Google Scholar
  8. 8.
    Balaguer-Meler J, Torres Rodriguez JM. Intertrigo interdigitaux par Fusarium solani. Bull Soc Fr Mycol Med 1984; 13:201–204.Google Scholar
  9. 9.
    Benjamin RP, Callaway JL, et al. Facial granuloma associated with Fusarium infection. Arch Dermatol 1970; 101:598–600.Google Scholar
  10. 10.
    Blazer BR, Hurd DD, Snover DC, et al. Fusarium infections in bone marrow transplant recipients. Am J Med 1984; 27:645–651.Google Scholar
  11. 11.
    Booth C. The genus Fusarium. Kew, Surrey, England: Commonwealth Mycological Institute, 1971.Google Scholar
  12. 12.
    Bourguignon RL, Walsh AF, et al. Fusarium species osteomyelitis: a case report. J Bone Joint Surg 1976; 58a:722–723.Google Scholar
  13. 13.
    Chaulk CP, Smith PW, Feagler JR, Verdirame J, Commers JR. Fungenia due to Fusarium solani in an immunocom-promised child. Ped Infec Dis 1986; 5:363–366.Google Scholar
  14. 14.
    Cho CT, Vast TS, et al. Fusarium solani infection during treatment of acute leukemia. J Pediatr. 1973; 83:1028–1031.Google Scholar
  15. 15.
    Collins MS, Rinaldi MG. Cutaneous infection in man caused by Fusarium moniliforme. Sabouraudia 1977; 15:151–160.Google Scholar
  16. 16.
    DiSalvo A, Fickling M. A case of nondermatophytic toe onychomycosis caused by Fusarium oxysporum. Arch Dermatol 1980; 6:699–700.Google Scholar
  17. 17.
    Gutman L, Chou SM, et al. Fusariosis, myasthenic syndrome and aplastic anemia. Neurology 1975; 25:922–926.Google Scholar
  18. 18.
    Harris JJ, Downham, TF. Unusual fungal infections associated with immunological hyporeactivity. Int J Dermatol 1978; 17:323–300.Google Scholar
  19. 19.
    Holzegel K, Kempf HF. Fusarium Mykose an der Haut eines Verbrannten. (Fusarium mycosis of the skin of a burned patient). Dermatol Wochenschr 1964; 150:651–658.Google Scholar
  20. 20.
    Imwidthaya S, Chuntrasakal C, Chantarakul N. Opportunistic fungal infections of burn wound. J Med Assoc Thailand 1984; 67:242–248.Google Scholar
  21. 21.
    Jakie C, Leek J, Olson DA, Robbins D. Septic arthritis due to Fusarium solani. J Rheumatology 1983; 10:151–153.Google Scholar
  22. 22.
    June CH, Beaty PG, Schulman HM, Rinaldi, MG. Disseminated Fusarium moniliforme infection after allogenic marrow transplants. So Med J 1986; 79:513–515.Google Scholar
  23. 23.
    Kerr CM, Perfect JR, Craven PC, Jorgensen JH, Drutz DJ, Shelburne JD, Gallis HA, Gutman RA. Fungal peritonitis in patients on continuous ambulatory peritoneal dialysis. Ann Inf Med 1983; 99:334–337.Google Scholar
  24. 24.
    Kidd GH, Wolf FT. Dimorphism in a pathogenic Fusarium. Mycologia 1973; 65:1371–1375.Google Scholar
  25. 25.
    Kiehn TE, Nelson PE, Bernard EM, Edwards FF, Koziner B, Armstrong D. Catheter-associated fungemia caused by Fusarium chlamydosporum in a patient with lympocytic lymphoma. J Clin Microbiol 1985; 21:501–504.Google Scholar
  26. 26.
    Krick JA, Remington JS. Opportunistic invasive fungal infections in patients with leukemia and lymphoma. Clin Haematol 1976; 5:249–310.Google Scholar
  27. 27.
    Kuttin ES, Mullar J, et al. Mykosen bei Krokodilen. Mykosen 1978; 21:39–48.Google Scholar
  28. 28.
    Lazarus JA, Schwarz LH. Infestation of urinary bladder with an unusual fungus strain, Fusarium. Urol Cutan Rev 1948; 52:185–189.Google Scholar
  29. 29.
    Matsuda T, Matsumoto T. Disseminated hyalohyphomycosis in a leukemic patient. Arch Dermatol 1986; 122:1171–1175.Google Scholar
  30. 30.
    McNeely DJ, Vas, SI, Donbros N, Oreopoulos, DG. Fusarium peritonitis an uncommon complication of continuous ambulatory peritoneal. Dialysis Bulletin 1981; 1:94–96.Google Scholar
  31. 31.
    Okudo C, Ito M, et al. Disseminated cutaneous Fusarium infection with vascular invasion in a leukemic patient. J Med Vet Mycol 1987; 25:177–186.Google Scholar
  32. 32.
    Mutton KJ, Lucas TJ, Harkness JL. Disseminated Fusarium infection. Med J Aust 1980; 2:624–625.Google Scholar
  33. 33.
    Page JC, Friedlander G, Dockery GL. Postoperative Fusarium osteomyelitis. J Foot Surgery 1982; 21:174–176.Google Scholar
  34. 34.
    Perez Villarroya JC, Fernandez-Guerrero ML, Moran V, et al. Fusarium oxysporum infection. J Infection 1982; 5:207–208.Google Scholar
  35. 35.
    Peterson JD, Baker JJ. An isolate of Fusarium roseum from human burns. Mycologia 1959; 51:453–56.Google Scholar
  36. 36.
    Placentini I, Biasioli S, Chiaramonte S, et al. Fusarium verticilloides nuovo patogeno opportunista. G Mal Infet Parasitol 1984; 36:64–67.Google Scholar
  37. 37.
    Steinberg GK, Britt RH, Enzmann DR. Fusarium brain abscess. J Neurosurgery 1983; 56:598–601.Google Scholar
  38. 38.
    Veglia KS, Murks VJ. Fusarium as a pathogen. J Am Acad Dermatol 1987; 16:260–263.Google Scholar
  39. 39.
    Wheeler MS, McGinnis MR, et al. Fusarium infection in burned patients. Am J Clin Pathol 1981; 75:304–311.Google Scholar
  40. 40.
    Williamsen MJ, Coninck AL, Coremans-Pelseneer JE, et al. Parasitic invasion of Fusarium oxysporum in an arterial ulcer in an otherwise healthy patient. Mykosen 1986; 29:248–252.Google Scholar
  41. 41.
    Young, CN, Meyers AM. Opportunistic fungal infection by Fusarium oxysporum in renal transplant patient. Sabouraudia 17:219–594.Google Scholar
  42. 42.
    Young NA, Kwon-Chung KJ, et al. Disseminated infection by Fusarium moniliforme during treatment for malignant lymphoma. J Clin Microbiol 1978; 7:589–594.Google Scholar
  43. 43.
    Zapater RC, Brunzini EJ, Albesi EJ, Arturi C.S. Silicaro. El genero fusarium como agente etiologico de micosis oculares. Archivos de Oftalmologia de Buenos Aires 1976: 51:279–286.Google Scholar

Copyright information

© Martinus Nijhoff/Dr W. Junk Publishers 1988

Authors and Affiliations

  • John W. Rippon
    • 1
  • Richard A. Larson
    • 1
  • Daniel M. Rosenthal
    • 1
  • Joseph Clayman
    • 1
  1. 1.Section of Dermatology and Joint Section of Hematology/Oncology, Department of MedicineUniversity of ChicagoChicagoUSA

Personalised recommendations