European Journal of Pediatrics

, Volume 146, Supplement 2, pp S56–S58 | Cite as

Treatment of cryptorchidism with low doses of buserelin over a 6-months period

  • F. Hadziselimovic
  • D. Huff
  • J. Duckett
  • B. Herzog
  • J. Elder
  • H. Snyder
  • M. Buser
Article

Abstract

In a collaborative study, 48 prepubertal boys with undescended testes ranging in age from 15 months to 11 years were treated with low-dose intranasal buserelin following an every-other-day programme for a period of 6 months. Urinary LH, FSH, and testosterone were not altered during the treatment period. Boys over 7 years of age experienced a slight but significant rise in testosterone at the end of treatment. Testicular descent was achieved in only 17% of boys. In the remainder, bilateral testicular biopsies were obtained during orchiopexy. Grouped analysis showed a significant increase in the number of germ cells per tubule in both unilateral and bilateral cryptorchid boys, suggesting that buserelin treatment of the testis in a cryptorchid position is capable of improving fertility potential. If time-matched controls are compared to treated boys of the same age, again a significant difference is observed indicating that buserelin treatment does increase the germ cell count.

Key words

Undescended testes Intranasal buserelin Testicular descent Fertility 

References

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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • F. Hadziselimovic
    • 1
  • D. Huff
    • 2
  • J. Duckett
    • 2
  • B. Herzog
    • 1
  • J. Elder
    • 2
  • H. Snyder
    • 2
  • M. Buser
    • 3
  1. 1.Basler KinderspitalBaselSwitzerland
  2. 2.Children's Hospital of PhiladelphiaPhiladelphiaUSA
  3. 3.University Computer CenterBaselSwitzerland

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