Abstract
Fifty-three prepubertal boys with unilateral (n=38) or bilateral (n=15) cryptorchidism were treated for 4 weeks with synthetic LH-RH (Cryptocur, Hoechst) 1.2 mg daily, divided into 3×400 μg and administered intranasally. Complete descent was observed in 54% of testes-37% in the boys with unilateral cryptorchidism and 77% in the boys with bilateral cryptorchidism. Follow-up examination 6 months after therapy showed relapse in 30%, and a second therapeutic trial with intranasal LH-RH was effective in all these cases. Treatment of cryptorchidism with intranasal synthetic LH-RH, 3×400 μg/day, seems to be very effective, painless and without major side effects. However, follow-up is mandatory.
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Borkenstein, M. Intranasal LH-RH for cryptorchidism: response to initial treatment and to treatment after relapse. Eur J Pediatr 146 (Suppl 2), S42–S43 (1987). https://doi.org/10.1007/BF00452870
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DOI: https://doi.org/10.1007/BF00452870