Abstract
The assay of urinary LH and FSH in first morning void urine can be used for the differential diagnosis between anorchism and bilateral cryptorchidism with impalpable testes. Furthermore, levels of urinary LH and FSH excretion and their response to intranasal stimulation with LH-RH prove helpful in the follow-up of patients under hormonal treatment, i.e. prolonged stimulation in hypogonadotrophic hypogonadism or suppression by an LH-RH analogue, for instance in precocious puberty. By increasing the sensitivity of the assay, the value of urinary gonadotrophins for the differential diagnosis and survey of hormonal treatment in very young children can be examined, and investigations of this kind are currently taking place. The method used obviously cannot assess the bioactivity of the excreted hormone, nor can it depict the pulsatility of gonadotrophin secretion.
We’re sorry, something doesn't seem to be working properly.
Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.
References
Bhasin S, Swerdloff RS (1986) Mechanisms of gonadotropin-releasing hormone agonist action in the human male. Endocr Rev 7:106–114
Girard J, Baumann JB, Ruch W (1980) Diagnostic possibilities in delayed puberty. In: Cacciari E, Prader A (eds) Pathophysiology of puberty. Serono Symposium No. 36. Academic Press, London New York, pp 223–237
Hadziselimovic F, Hoecht B, Herzog B, Girard J (1984) Does longterm treatment with Buserelin improve the fertility chances of cryptorchid testes? In: Labrie F, Belanger A, Dupont A (eds) LH-RH and its analogues. Elsevier. Amsterdam, pp 488–503
Kulin HE, Santner SJ (1977) Timed urinary gonadotropin measurement in normal infants, children and adults, and in patients with disorders of sexual maturation. J Pediatr 90:760–765
Santen RJ, Kulin HE (1986) Evaluation of delayed puberty and hypogonadism. In: Santen RJ, Swerdloff RS (eds) Male reproductive dysfunction. Dekker, New York Basel, pp 145–189
Santoro N, Filicori M, Crowley WF Jr (1986) Hypogonadotropic disorders in men and women: diagnosis and therapy with pulsatile gonadotropin-releasing hormone. Endocr Rev 7:11–23