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Hormonal regulation of testicular descent

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Abstract

The involvement of testosterone in testicular descent and the mechanism of testicular descent were analyzed and discussed.

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References

  1. Arnheim EE (1938) The treatment of underscended testes with gonadotropic hormones. J Mt Sinai Hosp 4:1036–1041

    Google Scholar 

  2. Bardin CW, Ross GT, Rifkind AB, Cargille CM, Lipsett MB (1969) Studies of the pituitary-Leydig cell axis in young men with hypogonadotropic hypogonadism and hyposmia: comparison with normal men, prepubertal boys and hypopituitary patients. J Clin Invest 48:2046–2056

    Google Scholar 

  3. Bergh A, Helander HF, Wahlquist L (1978) Studies on factors governing testicular descent in the rat — particularly the role of the gubernaculum testis. Int J Androl 1:342–356

    Google Scholar 

  4. Bergin WC, Gier HT, Marion GB, Coffman JR (1970) A developmental concept of equine cryptorchidism. Biol Reprod 3:82–92

    Google Scholar 

  5. Bigler JA, Hardy LM, Scott HV (1938) Cryptorchidism treated with gonadotropic principle. Am J Dis Child 55:273–294

    Google Scholar 

  6. Cacciari E Cicognani A, Pirazzoli P, Zappulla F, Tassoni P, Bernardi F, Salardi, S (1976) Hypophysogonadal function in the cryptorchid child: differences between unilateral and bilateral cryptorchids. Acta Endocrinol (Copenh) 83:182–189

    Google Scholar 

  7. Ch'in KY (1938) The endocrine glands of anencephalic foetuses. Chin Med J [Engl] 2:63–90

    Google Scholar 

  8. Curling JB (1840) Observations on the structure of the gubernaculum and on the descent of the testis in the foetus. Lancet II: 70–74

    Google Scholar 

  9. Edler JS, Issacs JT, Walsh PC (1982) Androgenic sensitivity of the gubernaculum testis: evidence for homronal/mechanical interaction in testicular descent. J Urol 127:170–176

    Google Scholar 

  10. Engle ET (1932) Experimentally induced descent of the testis in the Macacs monkey by hormones from the anterior pituitary and pregnancy urine. Endocrinology 16:513–520

    Google Scholar 

  11. Frey HL, Rajfer J (1984) The role of the gubernaculum and intrabdominal pressure in the process of testicular descent. J Urol 131:574–579

    Google Scholar 

  12. Frey HL, Peng S Rajfer J (1983) Synergy of androgens and abdominal pressure in testicular descent. Biol Reprod 29:1233–1239

    Google Scholar 

  13. Gendrel D, Job JC, Roger M (1978) Reduced postnatal rise of testosterone in plasma of cryptorchid children. Acta Endocrinol (Copenh) 89:372–378

    Google Scholar 

  14. Gendrel D, Chaussain JL, Roger M, Job JC (1980a) Simultaneous postnatal rise of plasma LH and testosterone in male infants. J Pediatr 97:600–602

    Google Scholar 

  15. Gendrel D, Roger M, Job JC (1980b) Plasma gonadotropin and testosterone values in infants with crytorchidism. J. Pediatr 97:217–220

    Google Scholar 

  16. Gier HT, Marion GB (1970) Development of the mammalian testis. In: Johnson AD, Gomes WR (eds) The testis. Academic Press, New York, pp 1–45

    Google Scholar 

  17. Goldman A, Stein L, Lapin J (1936) The treatment of undescended testes by the anterior, pituitary-like principle. NY State J Med 36:15–19

    Google Scholar 

  18. Grumbach MM, van Wyk J Jr (1974) Disorders of sex differentiation. In: Williams RH (ed) Textbook of endocrinology, 4th ed. Saunders, Philadelphia, pp 487–490

    Google Scholar 

  19. Hadziselimovic F (ed) (1983) Cryptorchidism. Management and implications. Springer Berlin Heidelberg New York

    Google Scholar 

  20. Hamilton JB (1938) The effect of male hormone upon the descent of the testes. Anat Rec 70:533–541

    Google Scholar 

  21. Hamilton JB, Hubert G (1938) Effect of synthetic male hormone substance on descent of testicles in human cryptorchidism. Proc Soc Exp Biol Med 39:4–5

    Google Scholar 

  22. Hunter JA (1841) A description of the situation of the testis in the fetus with its descent into the scrotum. In: Observations on certain parts of the animal oeconomy. Haswell, New Orleans, pp 42–50

    Google Scholar 

  23. Hunter RH (1927) The etiology of congenital inguinal hernia and abnormally placed testes. Br J Surg 14:125–130

    Google Scholar 

  24. Job JC, Gendrel D, Safar A, Roger M, Chaussain JL (1977) Pituitary LH and FSH and testosterone secretion in infants with undescended testes. Acta Endocrinol (Copenh) 85:644–649

    Google Scholar 

  25. Lemeh CN (1960) A study of the development and structural relationships of the testis and gubernaculum. Surg Gynecol Obstet 110:164–172

    Google Scholar 

  26. McMurrich JP (1923) The development of the human body. A manual of human embryology, 7th edn. Blakiston's Sone, Philadelphia, pp 374–376

    Google Scholar 

  27. Opitz JM, Simpson JL, Sarto GE, Summit RL, New M, German J (1972) Pseudovaginal perineoscrotal hypospadias. Clin Genet 3:1–26

    Google Scholar 

  28. Rajfer J (1982) An endocrinological study of testicular descent in the rabbit. J Surg Res 33:158–163

    Google Scholar 

  29. Rajfer J, Walsh PC (1977) Hormonal regulation of testicular descent: experimental and clinical observations. J Urol 118:985–990

    Google Scholar 

  30. Sadeghi-Nejad A, Senior B (1974) A familial syndrome of isolated aplasia of the anterior pituitary. J Pediatr 84:79–84

    Google Scholar 

  31. Santen RJ, Paulsen CA (1972) Hypogonadotropic eunuchoidism. Gonadal responsiveness to exogenous gonadotropins. J Clin Endocrinol Metab 36:47–54

    Google Scholar 

  32. Schechter J (1963) An investigation of the anatomical mechanisms of testicular descent Thesis for Master of Arts degree., Johns Hopkins University, Baltimore

    Google Scholar 

  33. Sizonenko PC, Schindler RA, Roland W, Paunier L Cuendet A (1978) FSH III: Evidence for a possible prepuberal regulation of its secretion by the seminiferous tubules in cryptorchid boys. J Clin Endocrinol Metab 46:301–308

    Google Scholar 

  34. Sonneland CG (1925) Undescended testicle. Surg Gynecol Obstet 40:535–542

    Google Scholar 

  35. Steiner MD, Boggs JD (1965) Absence of the pituitary gland, hypothyroidism, hypoadrenalism and hypogonadism in a 17 year old dwarf. J Clin Endocrinol Metab 25:1591–1598

    Google Scholar 

  36. Tayakkononta K (1963) The gubernaculum testis and its nerve supply. Aust NZ J Surg 33:61–67

    Google Scholar 

  37. Thompson WO, Bevan AD, Heckel NJ, McCarthy ER, Thompson PK (1937) The treatment of undescended, testes with anterior pituitary-like substance. Endocrinology 21:220–229

    Google Scholar 

  38. van Vliet G, Caufriez A, Robyn C, Wolter R (1980) Plasma gonadotropin values in prepubertal cryptorchid boys: similar increase of FSH in uni- and bilateral cases. J Pediatr 97:253–255

    Google Scholar 

  39. Walsh PC, Curry N, Mills RC, Siiteri PK (1976) Plasma androgen response to hCG stimulation in prepubertal boys with hypospadias and cryptorchidism. J Clin Endocrinol Metab 42:52–59

    Google Scholar 

  40. Walsh PC, Madden JD, Harrod MJ, Goldstein JL, MacDonal PC, Wilson JD (1974) Familial incomplete male pseudohermaphroditism, type 2. Decreased dihydrotestosterone formation in pseudovaginal perineoscrotal hypospadias. N Engl J Med 291:944–949

    Google Scholar 

  41. Wells LJ (1944) Descensus testiculorum: descent after severance of the gubernaculum. Anat Rec 88:465–466

    Google Scholar 

  42. Wyndham NR (1943) A morphological study of testicular descent. J Anat 77:179–188

    Google Scholar 

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Authors and Affiliations

  1. Division of Urology, Harbor/UCLA Medical Center, Box 5, 90509, Torrance, CA, USA

    J. Rajfer

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Rajfer, J. Hormonal regulation of testicular descent. Eur J Pediatr 146 (Suppl 2), S6–S7 (1987). https://doi.org/10.1007/BF00452858

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  • DOI: https://doi.org/10.1007/BF00452858

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