European Journal of Pediatrics

, Volume 144, Issue 2, pp 191–194 | Cite as

Anticoagulant therapy by continuous heparin-abtithrombin III infusion in newborns with disseminated intravascular coagulation

  • R. von Kries
  • H. Stannigel
  • U. Göbel
Original Investigations

Abstract

In ten newborns with severe alteration of the coagulation system due to DIC, AT III concentrate was infused continuously after prior activation with heparin. The rise in AT III activity showed a great variability among the infants and for one child during the course of the therapy. The mean rise of AT III activity by 40 U/kg per day heparin was 8.7%. If AT III concentrate (40 U/kg per day) was activated with 200 U/kg per day heparin, excessive anticoagulatory effect was only observed in one child. In four children who had failed to respond to prior heparin therapy, improvement of the coagulation status was achieved within 2 days.

Key words

Antithrombin III Newborns Disseminated intravascular coagulation Anticoagulant therapy 

Abbreviations

DIC

disseminated intravascular coagulation

AT III

antithrombin III

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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • R. von Kries
    • 1
  • H. Stannigel
    • 1
  • U. Göbel
    • 2
  1. 1.Abteilung für Neonatologie und GastroenterologieZentrum für Kinderheilkunde der Universität DüsseldorfFederal Republic of Germany
  2. 2.Abteilung für Pädiatrische Hämatologie und OnkologieZentrum für Kinderheilkunde der Universität DüsseldorfFederal Republic of Germany

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