European Journal of Pediatrics

, Volume 144, Issue 2, pp 164–166 | Cite as

Biphasic (early and late) asthematic responses to exercise in children with severe asthma, resident at high altitude

  • A. Boner
  • E. Niero
  • I. Antolini
  • J. O. Warner
Original Investigations


Twenty-three children with severe asthma who had been resident at high altitude for at least 3 months, considerably reduced their requirement for regular anti-asthma therapy. On a standard exercise challenge in low humidity, ten had no response, seven had isolated immediate bronchospasm and six had biphasic responses with immediate bronchospasm followed 4–10 h later by a late reaction sustained for at least 2h. The existence of biphasic responses after exercise, similar to those observed after antigen challenge, supports the concept of mast cell involvement in exercise-induced asthma.

Key words

Asthma Exercise Bronchial hyperreactivity Late reaction 



exercise-induced asthma


peak expiratory flow rate


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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • A. Boner
    • 1
  • E. Niero
    • 1
  • I. Antolini
    • 1
  • J. O. Warner
    • 2
  1. 1.Clinica PediatricaUniversity of Verona and Villagio AlpinoMisurinaItaly
  2. 2.Paediatric Respiratory UnitThe Brompton HospitalLondonUK

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