Summary
Eleven patients with sickle cell disease and neurological symptoms underwent MRI examination. Cerebral infarcts of two types were found, those in the vascular distribution of the middle cerebral artery and those in the deep white matter. In the patient whose hydration and whose oxygenation of erythrocytes has been treated, MRI offers diagnostic advantages over arteriography and CT.
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References
Hughes JG, Diggs LW, Gillespie CE (1940) The involvement of the nervous system in sickle cell anemia. J Pediatr 17: 166
Portnoy BA, Herion JC (1972) Neurological manifestations in sickle cell disease with a review of the literature and emphasis on the prevalence of hemiplegia. Ann Intern Med 76: 643
Powars D, Wilson B, Imbus C, Pegelow C, Allen J (1978) The natural history of stroke in sickle cell anemia. AM J Med 65: 461
Russell MO, Goldberg HI, Hodson A, Kim HC, Holus J, Reivich M, Schwartz E (1984) Effect of transfusion therapy on arteriographic abnormalities and on recurrence of stroke in sickle cell disease. Blood 63: 162
Richards D, Nulsen FE (1971) Angiographic media and the sickling phenomenon. Surg Forum 22: 403
Stockman JA, Nigro MA, Miskin MM, Oski FA (1972) Occlusion of large cerebral vessels in sickle cell anemia. N Engl J Med 287: 846
Brandt-Zawodski M, Weinstein P, Bartkowski H, Mosleley M (1987) MR imaging and spectroscopy in clinical and experimental cerebral ischemia: A review. AJNR 8: 39
Noguchi CT, Schecter AN (1981) The intracellular polymerization of sickle hemoglobin and its relevance to sickle cell disease. Blood 58: 1057
Gerald B, Sebes JI, Longston JW (1980) Cerebral infarction secondary to sickle cell disease: Arteriographic findings. AJR 134: 1209
Merkel KHH, Ginsberg PL, Parker JC, Donovan-Post MJ (1978) Cerebrovascular disease in sickle cell anemia: A clinical pathological and radiological correlation. Stroke 9: 45
Ladurner G, Soper WD, Iliff LD, Lechner H (1979) A correlation of clinical findings and CT in ischemic cerebrovascular disease. Em Neurol 18: 281
Murayama M (1965) Orientation of sickled erythrocytes in a magnetic field. Nature 206: 420
Brody AS, Sorette MP, Gooding CA, Listerud J, Clark MR, Mentzer WC, Brasch RC, James TL (1985) AUR Memorial Award — Induced alignment of flowing sickle erythrocytes in a magnetic field. A preliminary report. Invest Radiol 20: 560
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Zimmerman, R.A., Gill, F., Goldberg, H.I. et al. MRI of sickle cell cerebral infarction. Neuroradiology 29, 232–237 (1987). https://doi.org/10.1007/BF00451759
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DOI: https://doi.org/10.1007/BF00451759