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Further evidence for localization of the gene of erythrokeratodermia variabilis

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Summary

Close genetic linkage between erythrokeratodermia variabilis (EKV) and the Rh blood group system has been reported by our group. Here we describe the results of a linkage analysis in another EKV kindred, in which the disease segregated with the CDe genotype. Among 18 informative individuals, 1 recombinant was found. A maximum lod score of 4.21 was calculated at a recombination fraction of 0.03–0.04. Addition of this lod score to the earlier reported results gives a maximum lod score of 9.93 for linkage between EKV and Rh at a recombination fraction of 0.03 (95% confidence limits 0.008–0.11).

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Authors and Affiliations

  1. Department of Dermatology, University Hospital, Rijnsburgerweg 10, NL-2333 AA, Leiden, The Netherlands

    J. G. van der Schroeff

  2. Department of Clinical Genetics, University Hospital, Rijnsburgerweg 10, NL-2333 AA, Leiden, The Netherlands

    A. van Haeringen

  3. Department of Human Genetics, University of Leiden, Rijnsburgerweg 10, NL-2333 AA, Leiden, The Netherlands

    I. van Leeuwen-Cornelisse & L. N. Went

Authors
  1. J. G. van der Schroeff
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  2. I. van Leeuwen-Cornelisse
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  3. A. van Haeringen
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  4. L. N. Went
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van der Schroeff, J.G., van Leeuwen-Cornelisse, I., van Haeringen, A. et al. Further evidence for localization of the gene of erythrokeratodermia variabilis. Hum Genet 80, 97–98 (1988). https://doi.org/10.1007/BF00451466

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  • DOI: https://doi.org/10.1007/BF00451466

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