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Geriatric Nephrology and Urology

, Volume 2, Issue 3, pp 155–167 | Cite as

Pharmacokinetics in the elderly

  • Pierre Veyssier
Review Article
  • 64 Downloads

Abstract

The rapidly increasing proportion of persons over 65 years old is well known and is associated with a challenge for health care professionnels vis à vis the use of modern drug therapy, and a higher risk of adverse drug reactions. These reactions are often related to inappropriate therapy based on an incomplete knowledge of changes in drug handling in the elderly. Multiple disease, concomitant therapy, environmental conditions, social behaviour, compliance, changes in physiology with advancing age can all alter pharmacokinetics and pharmacodynamics of drugs. Age can modify drug absorption, metabolism, distribution and elimination. The changes associated with aging in drug interaction and the role of underlying clinical status are discussed. The pharmacokinetics of some drugs in the elderly are described. Careful attention to concomitant drug therapy for multiple disease is needed before prescribing for elderly patients.

Key words

Pharmacokinetics elderly 

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Copyright information

© Kluwer Academic Publishers 1992

Authors and Affiliations

  • Pierre Veyssier
    • 1
  1. 1.Centre Hospitalier de CompiegneFrance

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