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Toward drugs derived from cannabis

Abstract

Recent work aimed at the introduction of natural and synthetic cannabinoids as drugs is reviewed. Δ1-Tetrahydrocannabinol (Δ1-THC) is mainly investigated as a potential drug against glaucoma and asthma, and as an antiemetic agent in cancer chemotherapy. Cannabidiol is being tried in the clinic against epilepsy and as a hypnotic. Numerous synthetic cannabinoids are currently being investigated as analgetics and as sedative-relaxants.

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References

  1. 1.

    Rosenthal, F.: The Herb Hashish versus Mediaval Muslim Society. Leiden: E.J. Brill 1971

    Google Scholar 

  2. 2.

    Julien, S.: Acad. Sci. [D] (Paris) 28, 195 (1849)

    Google Scholar 

  3. 3.

    Walton, R.P.: Marihuana. America's New Drug Problem. Philadelphia: Lippincott 1938

    Google Scholar 

  4. 4.

    Mikuriya, T.H. (ed.): Marijuana. Medical Papers 1839–1972. Oakland, California: Medi-Comp Press 1973

    Google Scholar 

  5. 5.

    O'Shoughnessy, W.B.: Trans. Med. Phys. Soc. Bombay 421 (1842)

  6. 6.

    Reynolds, J.R.: Lancet 1890-I, 637

  7. 7.

    For a review see: Mechoulam, R. (ed.): Marijuana. Chemistry, Pharmacology, Metabolism and Clinical Effects. New-York: Academic Press 1973

    Google Scholar 

  8. 8.

    Gaoni, Y., Mechoulam, R.: J. Am. Chem. Soc. 86, 1646 (1964)

    Google Scholar 

  9. 9.

    Mechoulam, R., Burstein, S., McCallum, N.K.: Chem. Rev. 76, 75 (1976); Braude, M.C., Czara, S. (eds.): Pharmacology of Marihuana. New York: Raven Press 1976; Graham, J.D.P. (ed.): Cannabis and Health. London-New York: Academic Press 1976

    Google Scholar 

  10. 10.

    Benowitz, N.L., Jones, R.T.: Clin. Pharmacol. Ther. 21, 336 (1977)

    Google Scholar 

  11. 11. a)

    Cohen, S., Stillman, R.C. (ed.): The Therapeutic Potential of Marihuana. New York: Plenum Med. Book Co. 1976

    Google Scholar 

  12. 11. b)

    Archer, R.A.: Ann. Rep. Med. Chem. 9, 253 (1974)

    Google Scholar 

  13. 12.

    Hepler, R.S., Frank, I.M.: JAMA 217, 1392 (1971)

    Google Scholar 

  14. 13.

    Hepler, R.S., Petrus, R.J., in: [11a], p. 63

    Google Scholar 

  15. 14.

    Mechoulam, R., et al., in: [11a], p. 35.

    Google Scholar 

  16. 15.

    Green, K., Kim, K.: Proc. Soc. Exp. Biol. Med. 154, 228 (1977)

    Google Scholar 

  17. 16.

    Vachon, L., et al.: N. Engl. J. Med. 288, 985 (1973)

    Google Scholar 

  18. 17.

    Tashkin, D.P., Shapiro, B.J., Frank, I.M.: Am. Rev. Resp. Dis. 109, 420 (1974)

    Google Scholar 

  19. 18.

    Vachon, L., Robins, A., Gaensler, E.A., in: [11a], p. 111

    Google Scholar 

  20. 19.

    Tashkin, D.P., et al.: Am. Rev. Resp. Dis. 115, 57 (1977)

    Google Scholar 

  21. 20.

    Abboud, R.T., Sanders, H.D.: Chest 70, 480 (1976)

    Google Scholar 

  22. 21.

    Salan, S.E., Zinberg, N.B., Frei, E.: N. Engl. J. Med. 293, 795 (1975)

    Google Scholar 

  23. 22.

    Benowitz, N.L., Jones, R.T.: Clin. Pharmacol. Ther. 18, 287 (1975)

    Google Scholar 

  24. 23.

    Sofia, R.D., et al.: J. Pharmacol. Exp. Ther. 186, 646 (1973); Sofia, R.D., et al.: Life Sci. 15, 251 (1974)

    Google Scholar 

  25. 24.

    Kosersky, D.S., Dewey, W.L., Harris, L.S.: Eur. J. Pharmacol. 24, 1 (1973)

    Google Scholar 

  26. 25.

    Gordon, R., Gordon, R.J., Sofia, R.D.: ibid. 35, 309 (1976)

    Google Scholar 

  27. 26.

    Nir, I., et al.: Nature 244, 470 (1973); Ayalon, D., et al.: Neuroendocrinology 23, 31 (1977)

    Google Scholar 

  28. 27.

    Vitez, T.S., et al.: Anaesthesiology 38, 525 (1973)

    Google Scholar 

  29. 28.

    Cousens, K., DiMascio, A.: Psychopharmacologia 33, 355 (1973)

    Google Scholar 

  30. 29.

    Nahas, G.G. (ed.): Marihuana, Chemistry, Biochemistry, and Cellular Effects. Berlin-Heidelberg-New York: Springer 1976

    Google Scholar 

  31. 30.

    Greenberg, J.H., Saunders, M.E., Mellors, A.: Science 197, 475 (1977)

    Google Scholar 

  32. 31.

    Zimmerman, S., et al.: Pharmacology 15, 10 (1977)

    Google Scholar 

  33. 32.

    Petersen, B.H., Graham, J., Lemberger, L.: Life Sci. 19, 395 (1976); Lau, R.J., et al.: Science 192, 805 (1976); White, S.C., Brin, S.C., Janicki, B.W.: ibid. 188, 71 (1975)

    Google Scholar 

  34. 33.

    Carlini, E.A., et al.: J. Pharm. Pharmacol. 25, 664 (1973)

    Google Scholar 

  35. 34.

    Izquierdo, I., Orsinger, O.A., Berardi, A.C.: Psychopharmacologia 28, 95 (1973)

    Google Scholar 

  36. 35.

    Turkanis, S.A., et al.: Res. Commun. Chem. Pathol. Pharmacol. 2, 213 (1974); Consroe, P., Wolkin, A.: J. Pharmacol. Exp. Ther. 201, 26 (1977)

    Google Scholar 

  37. 36.

    Cunha, J.M., et al.: Abstr. Conf. Psychotropic Drug Action with Special Reference to Cannabinoids, Arad, Israel 1977; work still in progress

  38. 37.

    Winek, C.L.: Clin. Toxicol. 10, 243 (1977)

    Google Scholar 

  39. 38.

    Bicher, H.I., Mechoulam, R.: Arch. Int. Pharmacodyn. 172, 24 (1968)

    Google Scholar 

  40. 39.

    Wilson, R.S., May, E.L.: J. Med. Chem. 18, 700 (1975)

    Google Scholar 

  41. 40.

    Burstein, S.H., et al.: Nature 225, 87 (1970); Ben-Zvi, Z., Mechoulam, R., Burstein, S.: J. Am. Chem. Soc. 92, 3468 (1970)

    Google Scholar 

  42. 41.

    Hollister, L.E.: Pharmacology 11, 3 (1974)

    Google Scholar 

  43. 42.

    Wilson, R.S., et al.: J. Med. Chem. 19, 1165 (1976)

    Google Scholar 

  44. 43.

    Martin, B.R., et al.: Res. Commun. Chem. Pathol. Pharmacol. 16, 187 (1977)

    Google Scholar 

  45. 44.

    Lemberger, L., Rowe, H.: Clin. Pharmacol. Ther. 18, 720 (1975); [11a], p. 405.

    Google Scholar 

  46. 45.

    Dren, A.T., in: [11a], p.439

    Google Scholar 

  47. 46.

    Pars, H.G., Razdan, R.K., in: [11a], p.419

    Google Scholar 

  48. 47.

    Sidell, F.R., et al.: Proc. Soc. Exp. Biol. Med. 142, 867 (1973)

    Google Scholar 

  49. 48.

    Mechoulam, R., Edery, H., in: [7], p. 101

    Google Scholar 

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Mechoulam, R., Carlini, E.A. Toward drugs derived from cannabis. Naturwissenschaften 65, 174–179 (1978). https://doi.org/10.1007/BF00450585

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Keywords

  • Asthma
  • Recent Work
  • Glaucoma
  • Potential Drug
  • Cancer Chemotherapy