Archives of orthopaedic and traumatic surgery

, Volume 105, Issue 6, pp 326–331 | Cite as

Internal pressure and oxygen tension of bone tumors and tumorous conditions

  • M. Chigira
Original Articles


Internal pressure and oxygen tension were measured in 24 patients with bone tumors and tumorous conditions. High internal pressures were observed in most of the rapidly growing lesions. The internal pressures of slowly growing and non-growing lesions were not different from those of normal bone marrow. Oxygen tension was commonly higher in the rapidly growing lesions than in simulataneously obtained peripheral venous samples from the same patients. The oxygen tension of the fluid from simple bone cysts was lower than that in venous samples from the same patients. There is a good correlation between internal pressure and the growth rate of the bone lesions in this study. It is suggested that internal pressure and oxygen tension of the lesions demonstrated the degree of blood supply to the bone tumors and tumorous conditions.


Oxygen Public Health Growth Rate Bone Marrow Blood Supply 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Algire GH, Chalkley HW (1945) Vascular reactions of normal and malignant tissue in vivo. I. Vascular reaction of mice to wounds and to normal and neoplastic transplants. JNCI 6:73–85Google Scholar
  2. 2.
    Algire GH, Legallais FH (1951) Vascular reactions of normal and malignant tissue in vivo. IV. The effect of peripheral hypotension on transplanted tumors. INCI 12:399–421Google Scholar
  3. 3.
    Arnoldi CC, Linderholm H, Mussbichler H (1972) Venous engorgement and intraosseous hypertension in osteoarthritis of the hip. J Bone Joint Surg [Br] 54:409–421Google Scholar
  4. 4.
    Arnoldi CC, Limperg RK, Linderholm H (1975) Intraosseous hypertension and pain in the knee. J Bone Joint Surg [Br] 57:360–363Google Scholar
  5. 5.
    Bierman HR, Byron RL Jr, Kelly KH, Grady A (1951) Studies on the blood supply of tumors in man. III. Vascular patterns of the liver by hepatic arteriography in vivo. JNCI 12:107–131Google Scholar
  6. 6.
    Bierman HR, Kelly KH, Grace S (1952) Studies on the blood supply of tumors in man. IV. The increased oxygen content of venous blood-draining neoplasms. JNCI 12:701–707Google Scholar
  7. 7.
    Braithwaite JL (1958) The arterial supply of benzpyreneinduced tumors in the rat. Br J Cancer 12:75–80Google Scholar
  8. 8.
    Breedis C, Young G (1954) The blood supply of neoplasms in the liver. Am J Pathol 30:969–985Google Scholar
  9. 9.
    Chigira M, Maehara S, Arita S, Udagawa E (1983) Aetiology and treatment of simple bone cyst. J Bone Joint Surg [Br] 65:633–637Google Scholar
  10. 10.
    Dos Santos R (1950) Arteriography in bone tumors. J Bone Joint Surg [Br] 32:17–29Google Scholar
  11. 11.
    Folkman J (1971) Tumor angiogenesis. N Engl J Med 285:1182–1186Google Scholar
  12. 12.
    Folkman J, Merler E, Abernathy C, Williams G (1971) Isolation of a tumor factor responsible for angiogenesis. J Exp Med 133:275–288Google Scholar
  13. 13.
    Folkman J, Hochberg M (1973) Self-regulation of growth in three dimensions. J Exp Med 138:745–753Google Scholar
  14. 14.
    Gimbrone MA Jr, Leapman SB, Cotran RS, Folkman J (1972) Tumor dormancy in vivo by prevention of neovascularization. J Exp Med 261–276Google Scholar
  15. 15.
    Gimbrone MA Jr, Cotran RS, Leapman SB, Folkman J (1974) Tumor growth and neovascularization: a experimental model using the rabbit cornea. JNCI 52:413–427Google Scholar
  16. 16.
    Goldacre RJ, Sylven B (1969) A rapid method of studying tumor blood supply using systemic dyes. Nature 184:63–64Google Scholar
  17. 17.
    Greene HSN (1941) Heterologous transplantation of mammalian tumors. J Exp Med 73:461–474Google Scholar
  18. 18.
    Gullino PM, Grantham FH (1961) Studies on the exchange of fluid between host and tumor. II. The blood flow of hepatomas and other tumors in rats and mice. JNCI 27:1465–1491Google Scholar
  19. 19.
    Langer R, Conn H, Vacanti J, Haudenschid C, Folkman J (1980) Control of tumor growth in animals by infusion of an angiogenesis inhibitor. Proc Natl Acad Sci USA 77:4331–4335Google Scholar
  20. 20.
    Lodwick GS, Wilson AJ, Farrell C, Virtama P, Dittrich F (1980) Determining growth rates of focal lesions of bone from radiographs. Radiology 134:577–583Google Scholar
  21. 21.
    Owen LN (1960) A rapid method for studying tumor blood supply using lyssamine green. Nature 187:795–796Google Scholar
  22. 22.
    Petrakis ML (1954) Bone marrow pressure in leukemic and nonleukemic patients. J Clin Invest 33:27–34Google Scholar
  23. 23.
    Shim S, Hawk HE, William YY (1972) The relationship between blood flow and marrow cavity pressure of bone. Surg Gynecol Obstet 135:353–360Google Scholar
  24. 24.
    Urbach F, Noell WK (1958) Effects of oxygen breathing on tumor oxygen measured polarographically. J Appl Physiol 13:61–65Google Scholar
  25. 25.
    Wilkes CH, Visscher MB (1975) Some physiological aspects of bone marrow pressure. J Bone Joint Surg [Am] 57A:49–57Google Scholar

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • M. Chigira
    • 1
  1. 1.Department of Orthopedic SurgeryGunma University School of MedicineMaebashi, GunmaJapan

Personalised recommendations