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European Journal of Nuclear Medicine

, Volume 15, Issue 7, pp 373–375 | Cite as

Enhancement of clearance of plant lectins as radiopharmaceuticals by chemically glycosylated antilectin antibody

  • S. Kojima
  • M. Imagawa
  • H. J. Gabius
Article

Abstract

The influence of chemical glycosylation on clearance of plant lectins, employed as radiopharmaceuticals, was assessed. Controlled chemical modification of the antibody to concanavalia ensiformis agglutinin did not affect its immunologic activity, but led to rapid clearance from circulation. In tumor-bearing mice, notable increases of selected tumor/non tumor ratios even after only 1 h of presence of the galactosylated antibody to the lectin in circulation were observed. Similarly, galactosylated antibody to pisum sativum agglutinin caused significant increases of tumor/non tumor ratios.

Key words

Lectin Tumor Glycosylated antibody Radiopharmaceuticals 

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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • S. Kojima
    • 1
  • M. Imagawa
    • 2
  • H. J. Gabius
    • 3
  1. 1.Faculty of Pharmaceutical SciencesTeikyo UniversitySagamiko, KanagawaJapan
  2. 2.Faculty of Pharmaceutical SciencesOsaka UniversitySuita OsakaJapan
  3. 3.Abteilung ChemieMax-Planck-Institut für Experimentelle MedizinGöttingenFederal Republic of Germany

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