, Volume 76, Issue 4, pp 377–380 | Cite as

Serum neuroleptic concentrations and tardive dyskinesia

  • Dilip V. Jeste
  • Markku Linnoila
  • Richard L. Wagner
  • Richard Jed Wyatt
Original Investigations


Using a liquid chromatographic assay, we measured serum neuroleptic concentrations in eight middle-aged or elderly female inpatients with tardive dyskinesia (TD) and eight controls. All 16 patients were receiving either thioridazine or mesoridazine at stable doses. TD patients were found to have a significantly higher ratio of serum concentration to daily dose of neuroleptics compared with controls. A 1-year follow-up revealed that this ratio did not change appreciably in those patients who continued to receive neuroleptics. Differences in serum neuroleptic levels were not related to peripheral inflammatory activity as indicated by serum α-1-acid glycoprotein concentrations. Of the various thioridazine metabolites, sulforidazine (which is reportedly the most potent in terms of affinity for dopaminergic and α-noradrenergic receptors) seemed to be significantly elevated in the serum of TD patients as compared with non-TD patients. Our data suggest a need for further pharmacokinetic investigations to study neuroleptic metabolism in patients with TD.

Key words

Tardive dyskinesia Neuroleptic Serum thioridazine concentration Serum glycoprotein 


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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • Dilip V. Jeste
    • 1
  • Markku Linnoila
    • 2
  • Richard L. Wagner
    • 1
  • Richard Jed Wyatt
    • 1
  1. 1.Adult Psychiatry Branch, Division of Special Mental Health Research, Intramural Research Program, National Institute of Mental HealthSaint Elizabeths HospitalWashington, D.C.USA
  2. 2.Clinical Psychobiology BranchNational Instittte of Mental HealthBethesdaUSA

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