Psychopharmacology

, Volume 76, Issue 4, pp 333–340 | Cite as

Behavioural effects of electrolytic and 6-hydroxydopamine lesions of the accumbens and caudate-putamen nucleic

  • Roger O. A. Makanjuola
  • George W. Ashcroft
Original Investigations

Abstract

Selective bilateral destruction of dopaminergic neuronal terminals in the accumbens nuclei with 6-hydroxydopamine reduced spontaneous and amphetamine-induced locomotor and exploratory behaviour and sniffing activity; amphetamine-induced stereotyped behaviour appeared to be mildly potentiated. Similarly induced bilateral destruction of dopaminergic nerve endings in the caudateputamen reduced spontaneous activity; amphetamine-induced stereotyped behaviour was abolished. Some animals with severe degrees of neostriatal dopamine depletion were completely unresponsive to amphetamine, apart from intense sniffing activity. Bilateral electrolytic lesions of the accumbens nuclei did not alter spontaneous or amphetamine-induced activity.

Key words

Automated hole board Exploratory behaviour Locomotion Stereotyped behaviour Amphetamine 6-Hydroxydopamine Electrolytic lesions Nucleus accumbens Caudate-putamen Dopamine 

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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • Roger O. A. Makanjuola
    • 1
  • George W. Ashcroft
    • 1
  1. 1.Medical Research Council Brain Metabolism UnitUniversity Department of PharmacologyEdinburghScotland

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