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Cryptococcus neoformans varieties as agents of cryptococcosis in Brazil

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Abstract

The study of the clinical isolates of Cryptococcus neoformans from 83 Brazilian patients with disseminated cryptococcosis showed that 75 were C. neoformans var. neoformans and 8 were var. gattii. Twenty-seven isolates were serotyped; all 19 var. neoformans were serotype A and all 8 var. gattii were serotype B. The correlation of the varieties of C. neoformans with the presence or not of hosts predisposing conditions to the mycosis showed that: (1) cryptococcosis caused by gattii variety occurred in 7 (58.3%) of the 12 nonimmunosuppressed patients, and (2) cryptococcosis caused by neoformans variety occurred in 65 (98.5%) of the 66 AIDS patients and in all 5 patients with other immunosuppressive conditions. The comparison of the distribution of the gattii and neoformans varieties between the nonimmunosup-pressed and immunosuppressed patients showed a significant statistical difference (p < 0.01).

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Authors and Affiliations

  1. Serviço de Doenças Infecciosas e Parasitarárias, Hospital dos Servidores do Estado, Rio de Janeiro, RJ, Brasil

    Ronaldo Rozenbaum, Adrelirio José Rios Gonçalves & Hamilton Clemente

  2. Serviço de Micologia, Hospital Evandro Chagas, Institute Oswaldo Cruz, Rio de Janeiro, RJ, Brasil

    Bodo Wanke, Marcia dos Santos Lazera & Paulo Cesar Fialho Monteiro

  3. Serviço de Micologia, Hospital Universitário da Universidade Federal, Rio de Janeiro, RJ, Brasil

    Maria Julieta Caiuby

  4. Pesquisador 1-A do Conselho Nacional de Desenvolvimento Cientifico e Tecnológico/CNPq, Brasil

    Alberto Thomaz Londero

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  1. Ronaldo Rozenbaum
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  2. Adrelirio José Rios Gonçalves
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  3. Bodo Wanke
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  4. Maria Julieta Caiuby
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  5. Hamilton Clemente
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  6. Marcia dos Santos Lazera
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  7. Paulo Cesar Fialho Monteiro
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  8. Alberto Thomaz Londero
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Rozenbaum, R., Gonçalves, A.J.R., Wanke, B. et al. Cryptococcus neoformans varieties as agents of cryptococcosis in Brazil. Mycopathologia 119, 133–136 (1992). https://doi.org/10.1007/BF00448809

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  • DOI: https://doi.org/10.1007/BF00448809

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