European Journal of Nuclear Medicine

, Volume 2, Issue 1, pp 53–57 | Cite as

The relative stability of bleomycin metal complexes to metal exchange

  • Adrian D. Nunn
Article

Abstract

The resistance to exchange of the bound metal atom of carrier-free 111In bleomycin by excess cobalt2+ has been found to be markedly inferior to that of carrier-free 57Co bleomycin. After 1 h in the presence of excess copper more than 50% of the 111In has been removed from a bleomycin complex, whereas after 18 h less than 5% of the 57Co is removed from a similar bleomycin complex. The instability of caarier-free 111In bleomycin in the presence of copper is proposed as the first step in the pathway whereby transferrin bound 111In is formed when 111In bleomycin is used as a radiopharmaceutical.

Keywords

Public Health Copper Cobalt2 Nuclear Medicine Metal Complex 

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Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • Adrian D. Nunn
    • 1
  1. 1.Medical Research Council, Cyclotron UnitHammersmith HospitalLondonEngland

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