Abstract
Gastric acid secretion in nineteen children with celiac disease remained almost unchanged and the level of fasting serum gastrin was comparable with that of a control group of the same age. The absorption of vitamin B12 was significantly decreased, most clearly in the infants with celiac disease as compared with their controls. The serum B12 level, however, was decreased only in the oldest children. The results suggest that the mucosal lesion in the small intestine is most extensive in the youngest children, but the absorption defect of vitamin B12 becomes clinically significant only after a long duration of the disease and not in childhood.
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References
Carlmark, B., Reizenstein, P.: Comparison of methods to diagnose deficiency or malabsorption of vitamin B12. Scand. J. Gastroent. 9, Suppl. 29, 39–42 (1974)
Creutzfeldt, W., Ebert, R., Arnold, R., Frerichs, H., Brown, J. C.: Gastric inhibitory polypeptide (GIP), gastrin and insulin: Response to test meal in coeliac disease and after duodeno-pancreatectomy. Diabetologia 12, 279–286 (1976)
Fausa, O.: Vitamin B12 absorption in intestinal diseases. Scand. J. Gastroent. 9, 29, 75–79 (1974)
Kokkonen, J., Similä, S., Herva, R.: Impaired gastric function in children with cow's milk intolerance. (To be published)
Loehry, C. A., Craemer, B.: Vitamin B12 excretion by the rat small intestine. Gut 10, 662–664 (1969)
MacKinnon, A. M., Short, M. D., Elias, E., Dowling, R. H.: Adaptive changes in vitamin, B12 absorption in celiac disease and after proximal smallbowel resection in man. Dig. Dis. 20, 9, 835–840 (1975)
McNeish, A. S., Anderson, C. M.: Coeliac disease: The disorder in childhood. Clinics in gastroenterology 3, 1, 127–144 (1974)
Meeuwisse, G. W.: Diagnostic criteria in coeliac disease. Round table discussion. Acta Paediatr. Scand. 59, 461–463 (1970)
Molla, A. M., Eggermont, E.: Pepsin secretion in coeliac disease. Acta Paed. Belg. 25, 5, 269–281 (1971)
Nusslé, D., Frei, J., Bozic, C., Gautier, E.: Proximal and distal alterations of the intestinal mucosa in coeliac disease. Relations to the degree of malabsorption. In: Coeliac disease (ed. by Booth, C. C., Dowling, R. H.). Livingstone: Churchill 1970
O'Donoghue, D. P., Langaster-Smith, M., Johnson, G. D., Kumar, P. J.: Gastric lesion in dermatitis herpetiformis. Gut 17, 185–188 (1976)
Reinken, L., Zieglauer, H., Berger, H.: Vitamin B12 nutriture of children with acute, celiac disease in remission and of children with normal duodenal mucosa. Am. J. Clin. Nutr. 29, 750–753 (1976)
Silk, D. B. A., Kumar, P. J., Webb, J. P. W., Lane, A. E., Clark, M. L., Dawson, A. M.: Ileal function in patients with untreated adult celiac disease. Gut 16, 261–267 (1975)
Schjönsby, H., Andersen, K.-J.: The intestinal absorption of vitamin B12: Scand. J. Gastroent. 9, Suppl. 29, 7–11 (1974)
Steward, J. S., Pollock, D. J., Hoffbrand, A. V., Mollin, D. L., Booth, C. C.: A study of proximal and distal intestinal structure and absorptive function in idiopathic steatorrhoea. Quart. J. Med. 36, 143, 425–443 (1967)
Strober, W.: Gluten-sensitive enteropathy. Clinics in Gastroenterology 5, 2, 429–452 (1976)
Walsh, J. H., Grossman, M. I.: Gastrin (ABS). N. Engl. J. Med. 292, 25, 1324–1334 (1975)
Webb, M. G. T., Taylor, M. R. H., Gatenby, P. B. B.: Iron absorption in coeliac disease of childhood and adolescence. Brit. Med. J. 1967II, 151–152
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Kokkonen, J., Similä, S. Gastric function and absorption of vitamin B12 in children with celiac disease. Eur J Pediatr 132, 71–75 (1979). https://doi.org/10.1007/BF00447372
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DOI: https://doi.org/10.1007/BF00447372