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The in vitro interactions of candida albicans with nonspecific serum proteins

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Conclusions

Iron has a pivotal role in serum inhibition and filamentation. That there may be an inverse relationship between inhibition and filamentation is suggested by the observations that free serum iron abolishes inhibition and stimulates filamentation.

Evidence indicates that filamentation results from the interaction of substrates, growth conditions, and temperature, rather than from a single factor. Filamentation occurs during clumping and appears to be necessary for the manifestation of this later process, but any further relationship is unknown.

Opsonins seem to be a part of the complement system or their function at least is dependent upon complement activity. Their interaction with surface antigens form chemotactic stimulants but their contribution to the phagocytic destruction of C. Albicans is unclear. All of these serum-Candida interactions are in vitro observations. Although opsonization and phagocytosis probably play a vital role in the in vivo defenses against invading Candida, the contribution of these other interactions to host resistance remain unknown.

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Authors and Affiliations

  1. U.S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, 59840, Hamilton, Montana, USA

    H. F. Hasenclever

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  1. H. F. Hasenclever
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To prevent the repetitious use of terms germ tube formation, germination, filamentation, and Y → M conversion will be used interchangeably. All these terms have been used by various authors to describe this morphological event.

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Hasenclever, H.F. The in vitro interactions of candida albicans with nonspecific serum proteins. Mycopathologia 65, 169–176 (1978). https://doi.org/10.1007/BF00447187

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