, Volume 65, Issue 1–3, pp 169–176 | Cite as

The in vitro interactions of candida albicans with nonspecific serum proteins

  • H. F. Hasenclever
Mechanisms of Pathogenicity Among Zoopayhogens


Iron has a pivotal role in serum inhibition and filamentation. That there may be an inverse relationship between inhibition and filamentation is suggested by the observations that free serum iron abolishes inhibition and stimulates filamentation.

Evidence indicates that filamentation results from the interaction of substrates, growth conditions, and temperature, rather than from a single factor. Filamentation occurs during clumping and appears to be necessary for the manifestation of this later process, but any further relationship is unknown.

Opsonins seem to be a part of the complement system or their function at least is dependent upon complement activity. Their interaction with surface antigens form chemotactic stimulants but their contribution to the phagocytic destruction of C. Albicans is unclear. All of these serum-Candida interactions are in vitro observations. Although opsonization and phagocytosis probably play a vital role in the in vivo defenses against invading Candida, the contribution of these other interactions to host resistance remain unknown.


Iron Growth Condition Candida Pivotal Role Inverse Relationship 
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Copyright information

© Dr. W. Junk bv - Publishers 1978

Authors and Affiliations

  • H. F. Hasenclever
    • 1
  1. 1.U.S. Department of Health, Education, and Welfare, Public Health ServiceNational Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain LaboratoryHamiltonUSA

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