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Archives of Dermatological Research

, Volume 261, Issue 2, pp 123–134 | Cite as

Autoimmunity in psoriasis

A complement immunofluorescence study
  • Ernst H. Beutner
  • Maria Jarzabek-Chorzelska
  • Stefania Jablonska
  • Tadeusz P. Chorzelski
  • Genowefa Rzęsa
Original Papers

Summary

The stratum corneum (SC) antibodies are present in all human sera as seen by indirect immunofluorescent (IF) staining. They appear to bind in vivo to the stratum corneum of psoriatic lesions. They fix complement in vitro in a two step complement IF test system using either anti C4 or anti C3 conjugates as indicators. IF tests with proper controls showed that the SC antigen in psoriatic scales is coated not only with IgG but in a majority of the lesions also with complement. In the present studies in fully developed lesions complement was detectable in 88% of the specimens studied and in about 50% of very fresh linear lesions of unintentional Köbner type. These as well as some previously published observations afford indirect evidence for the participation of SC antibodies and the ensuing fixation of complement in the development of psoriatic lesions.

Keywords

Public Health Psoriasis Indirect Evidence Stratum Corneum Indirect Immunofluorescent 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Zusammenfassung

Antikörper gegen Stratum corneum (SC) befinden sich in Seren aller Menschen und können mittels der indirekten Immunofluorescenzmethode festgestellt werden. In Psoriasis-Herden scheinen sie in vivo im Stratum corneum fixiert zu sein. Sie fixieren Komplement in vitro, was man durch Komplement-Fixierungs-Tests unter Benutzung von anti C4 oder anti C3 Konjugaten beweisen kann. IF-Teste mit unterschiedlichen Kontrollen haben aufgezeigt, daß Stratum corneum als Antigen in Psoriasis-Läsionen nicht nur von IgG, sondern in der Mehrheit der Veränderungen auch von Komplement umgeben ist. In völlig entwickelten Läsionen wurde das Komplement in 88% der Biopsien festgestellt, weniger häufig — in ungefähr 50% — in sehr frühen linearen Hautveränderungen vom Typ des zufälligen Köbnerschen Phänomens. Diese und frühere Beobachtungen erbrigen einen indirekten Beweis, daß Antikörper SC an der Entstehung der Psoriasisherde teilnehmen, und die Komplementfixierung hier von Bedeutung sein könnte.

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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • Ernst H. Beutner
    • 1
  • Maria Jarzabek-Chorzelska
    • 2
  • Stefania Jablonska
    • 2
  • Tadeusz P. Chorzelski
    • 2
  • Genowefa Rzęsa
    • 2
  1. 1.Department of MicrobiologySuny at Buffalo, Schools of Medicine and DentistryBuffaloUSA
  2. 2.Department of DermatologyWarsaw Academy of MedicineWarsawPoland

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