Effect of 2-deoxyglucose, α-methylglucoside, and glucosamine on aflatoxin production by Aspergillus parasiticus
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The effects of 2-deoxyglucose (2-DOG), α-methylglucoside (α-MG), and glucosamine (GA) on aflatoxin production by Aspergillus parasiticus were studied using conidia-initiated and replacement cultures. In conidia-initiated, 2-DOG, α-MG, and GA supported varying amounts of growth when employed as sole carbon sources. In both conidia-initiated and replacement cultures, 2-DOG, but not α-MG nor GA, as sole carbon sources support toxin formation. None of the compounds inhibited aflatoxin production when used in combination with glucose. It appears that neither 2-DOG, α-MG, nor GA can be considered nonmetabolizable analogs of glucose in A. parasiticus.
Key wordsAflatoxins Aspergillus parasiticus Glucose analogs
yeast extract sucrose
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