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Presence of cyclopiazonic acid in kodo millet (Paspalum scrobiculatum) causing ‘kodua poisoning’ in man and its production by associated fungi

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Cyclopiazonic acid was isolated and identified from a sample of kodo millet seed that caused symptoms of ‘kodua poisoning’ in man. The extract of the toxic grain when injected intraperitoneally into mice produced symptoms of depression and complete loss of mobility. The seed was infected by Aspergillus flavus and A. tamarii and both fungi produced cyclopiazonic acid. This is the first report of the association of a mycotoxin with kodua poisoning and of A. tamarii with mycotoxicoses.

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  1. 1.

    Agarwal, O. N., S. S. Negi & V. Mahadevan, 1964. Studies on the toxicity and nutritive value of fungus free Paspalum scrobiculatum grains. Ind. Vet. J. 41: 43–47.

  2. 2.

    Bazlur M., 1960. Probable mona grass (P. commersoni) poisoning. Ind. Vet. J. 37: 31–34.

  3. 3.

    Bhide, N. K., 1962. Pharmacological study and fractionation of P. scrobiculatum extract. Brit. J. Pharmacol. 18: 7–18.

  4. 4.

    Dorner, J. W., 1983. Production of cyclopiazonic acid by Aspergillus tamarii Kita. Appl. Environ. Microbiol. 46: 1435–1437.

  5. 5.

    Holzapfel, C. W., 1968. The isolation and structure of cyclopiazonic acid, a toxic metabolite of Penicillium cyclopium Westling. Tetrahedron 24: 2101–2119.

  6. 6.

    Holzapfel, C. W., 1971. Cyclopiazonic acid and related toxins. Microbial toxins, Vol. VI: 443.

  7. 7.

    Lansden, J. A. & J. L. Davidson, 1983. Presence of cyclopiazonic acid in peanuts. Appl. Environ. Microbiol. 45: 766–769.

  8. 8.

    Le Bars, J., 1979. Cyclopiazonic acid production by Penicillium camemberti Thom and natural occurrence of this mycotoxin in cheese. Appl. Environ. Microbiol. 38: 1052–1055.

  9. 9.

    Luk, K. C., B. Kobbe & J. M. Townsend, 1977. Production of cyclopiazonic acid by Aspergillus flavus Link. Appl. Environ. Microbiol. 33: 211–212.

  10. 10.

    Nayak, N. C. & D. B. Misra, 1962. Cattle poisoning by Paspalum scrobiculatum (kodua poisoning). Ind. Vet. J. 39: 501–504.

  11. 11.

    Ohmomo, S. M., M. Sugita & M. Abe, 1973. Isolation of cyclopiazonic acid, cyclopiazonic acid imine and bissecodehydro cyclopiazonic acid from the cultures of Aspergillus versicolor (Vull) Tiraboschi. J. Agric. Chem. Soc. Jpn. 47: 83–89.

  12. 12.

    Orth, R., 1977. Mycotoxins of Aspergillus oryzae strains for use in the food industry as starters and enzyme producting molds. Ann. Nutr. Aliment 31: 617–624.

  13. 13.

    Still, P. E., C. Eckardt & L. Leistner, 1978. Bildung von Cyclopiazonsaure durch Penicillium camemberti — Isolate von Kase. Fleischwirtschaft 58: 876–877.

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Rao, B.L., Husain, A. Presence of cyclopiazonic acid in kodo millet (Paspalum scrobiculatum) causing ‘kodua poisoning’ in man and its production by associated fungi. Mycopathologia 89, 177–180 (1985).

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  • Depression
  • Aspergillus
  • Complete Loss
  • Cyclopiazonic Acid
  • Associate Fungus