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Repair of DNA damage in light sensitive human skin diseases

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Summary

Repair of UV-light induced DNA damage and changes in the semiconservative DNA synthesis were studied by in vitro autoradiography in the skin of patients with lightdermatoses (polymorphous light eruption, porphyria cutanea tarda, erythropoietic protoporphyria) and xeroderma pigmentosum as well as in that of healthy controls. In polymorphous light eruption the semiconservative DNA replication rate was more intensive in the area of the skin lesions and in the repeated phototest site, the excision repair synthesis appeared to be unaltered. In cutaneous porphyrias a decreased rate of the repair incorporation could be detected. Xeroderma pigmentosum was characterized by a strongly reduced repair synthesis.

Zusammenfassung

Die Reparatur der UV-Licht-induzierten DNS-Schäden und die Veränderungen in der semikonservativen DNS-Synthese wurden durch in vitro-Autoradiographie in der Haut von Lichtdermatose-Patienten (polymorphen Lichtdermatosen, Porphyria cutanea tarda, erythropoetische Protoporphyrie) und von Patienten mit Xeroderma pigmentosum untersucht. In den Fällen mit polymorpher Lichtdermatose war die semikonservative DNS-Replikation intensiver in den klinisch befallenen Hautfeldern und denen der wiederholten Phototeste. Die unprogrammierte DNS-Synthese war unverändert In den Fällen mit Porphyrien war eine verminderte Rate der Repair-Replikation nachzuweisen. Bei dem Patienten mit Xeroderma pigmentosum war die Reparaturkapazität stark erniedrigt.

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Authors and Affiliations

  1. Department of Dermatology, University Medical School, H-4012, Debrecen

    Irene Horkay & P. Tamási

  2. Frederic Joliot-Curie National Research Institute for Radiobiology and Radiohygiene, H-Budapest 22, Hungary

    L. Varga & S. Gundy

Authors
  1. Irene Horkay
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  2. L. Varga
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  3. P. Tamási
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  4. S. Gundy
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Horkay, I., Varga, L., Tamási, P. et al. Repair of DNA damage in light sensitive human skin diseases. Arch Dermatol Res 263, 307–315 (1978). https://doi.org/10.1007/BF00446947

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  • DOI: https://doi.org/10.1007/BF00446947

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