Molecular and General Genetics MGG

, Volume 151, Issue 1, pp 35–39 | Cite as

A new bacterial gene (groPC) which affects λ DNA replication

  • C. P. Georgopoulos


A bacterial mutation affecting λ DNA replication, called groPC756, has been mapped between the thr and leu bacterial loci. Most of the parental λ DNA does not undergo even one round of replication in this host. Lambda mutants, called π, which map in the λ P gene are able to overcome the inhibitory effect of the groPC756 mutation. It is shown that the mutation at the groPC locus also interferes with bacterial growth at 42°C. A λ-transducing phage, carrying the groPC+ allele, was isolated as a plaqueformer on groPC756 bacteria. Upon lysogenization, it restores both the gro+ and temperature resistant phenotypes.


Bacterial Growth Bacterial Gene Resistant Phenotype Bacterial Mutation Bacterial Locus 
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Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • C. P. Georgopoulos
    • 1
  1. 1.Department de Biologie MoléculaireUniversité de GenèveGenèveSwitzerland

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