Archives of Dermatological Research

, Volume 263, Issue 1, pp 59–66 | Cite as

Acidic glycosaminoglycans in skin and urine of a patient with wide-spreaded Lichen Sclerosus et Atrophicus

  • Hideo Yoshima
  • Hiroshi Shinkai
  • Shigeharu Sano
  • Makoto Homma
Original Papers


Changes of dermal and urinary acidic glycosaminoglycans in Lichen Sclerosus et Atrophicus (LSA) were investigated with the following results:
  1. 1.

    Hyaluronic acid (HA) was excreted in urine of a patient with LSA.

  2. 2.

    HA and low sulfate chondroitin were eluted with 0.5 M NaCl by Bio Rad AG 1-×2 (Cl- form) column chromatography.

  3. 3.

    Involved dermal tissue contained only about 50% of HA in the skin of a healthy adult.


Key words

Lichen sclerosus et atrophicus Characteristic glycosaminoglycans 


Die Veränderung der dermalen und im Urin nachweisbaren sauren Glykosaminoglykane beim Lichen sclerosus et atrophicus zeigten, daß 1. Hyaluronsäure im Urin nachgewiesen wurde, 2. Hyaluronsäure und Niedersulfat-Chondroitin mitteld 0,5 M NaCl durch Bio Rad AG 1-×2 Säulenchromatographie eluiert werden konnte, 3. die veränderte Haut nur etwa 50% der Hyaluronsäure gesunder Probanden enthält.


Lichen sclerosus et atrophicus Glykosaminoglykane 


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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • Hideo Yoshima
    • 1
  • Hiroshi Shinkai
    • 1
  • Shigeharu Sano
    • 1
  • Makoto Homma
    • 2
  1. 1.Department of DermatologyOsaka University School of MedicineOsakaJapan
  2. 2.Department of DermatologyHimeji National HospitalHimeji-shi, Hyogo-kenJapan

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