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Depressed non-specific lymphocyte reactivity in psoriasis

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Summary

T-lymphocyte number and functions were studied in 24 patients with psoriasis guttata as compared to healthy controls. A decrease was found of the in vitro ability to synthetize DNA in response to stimulation with phytohemaglutinin (PHA), concanavalin A, poke weed mitogen and PPD, which was statistically significant for PHA. The percentage and absolute numbers of both T and B peripheral blood lymphocytes were not altered.

Zusammenfassung

Die Zahl der T-Lymphocyten und ihre Funktionen wurden bei 24 Patienten mit Psoriasis guttata mit denen der gesunden Kontrollen verglichen. Auf Stimulation mit Phytohemagglutinin (PHA), Concanavalin A und PPD zeigte sich eine verminderte Fähigkeit, in vitro DNS zu synthetisieren. Der Prozentsatz und die absolute Zahl sowohl der T-als auch der B-Lymphocyten zeigten keine Veränderungen.

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Authors and Affiliations

  1. Institute of Medical Microbiology, University of Göteborg, Sahlgren's Hospital, S-41345, Göteborg, Sweden

    L. Lindholm, B. -L. Magnusson & H. Mobacken

  2. Department of Dermatology, University of Göteborg, Sahlgren's Hospital, S-41345, Göteborg, Sweden

    L. Lindholm, B. -L. Magnusson & H. Mobacken

Authors
  1. L. Lindholm
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  2. B. -L. Magnusson
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  3. H. Mobacken
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Lindholm, L., Magnusson, B.L. & Mobacken, H. Depressed non-specific lymphocyte reactivity in psoriasis. Arch Dermatol Res 263, 121–125 (1978). https://doi.org/10.1007/BF00446432

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  • DOI: https://doi.org/10.1007/BF00446432

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