European Journal of Pediatrics

, Volume 145, Issue 3, pp 182–184 | Cite as

Auto-immunity in children with diabetes mellitus and in their relatives

  • R. Lorini
  • D. Larizza
  • C. Livieri
  • V. Cammareri
  • A. Martini
  • A. Plebani
  • D. Zanaboni
  • F. Severi
Original Investigations


Islet cell antibodies (ICA-IgG and complement-fixing-ICA), parietal cell antibodies (PCA), intestinal epithelial cell antibodies (IECA), thyroglobulin (TgA) and thyroid microsomal antibodies (MsA), antinuclear (ANA) and reticulin antibodics (RA), were studied in 55 insulin-dependent diabetic patients (30 males and 25 females), aged 2–19 years with diabetes from a few days up to 14 years. In 58% of the diabetics one or more autoantibodies were found: ICA-IgG (31%), CF-ICA (16%), PCA (34%), TgA (9%), MsA (9%), ANA (13%), RA (2%). Autoantibodies were significantly more frequent in females (76%) than in males (43%) (P<0.025). ICA-IgG, CF-ICA, PCA, ANA were significantly more frequent in patients than in controls. The frequency of ICA-IgG and CF-ICA was significantly higher during the first 3 years of disease than afterwards (P<0.001); a similar pattern was observed for PCA, TgA, MsA. Of the 87 parents and 30 siblings screened for ICA-IgG, CF-ICA, PCA, IECA, TgA, MsA, ANA and RA, 42 (44%) had one or more autoantibodies, which were more frequent in females than in males. Seven relatives (6%) were ICA-IgG positive (four mothers, two fathers and one brother), and only one mother, ICA-IgG negative, was CF-ICA positive. Other autoantibodies were also more frequent in parents than in controls. Autoantibody-positive relatives have been asymptomatic up to now.

Key words

Type-I diabetes Islet cell antibodies Organ-specific autoimmunity Non-organ-specific autoimmunity 



islet cell antibodies


parietal cell antibodies


intestinal epithelial cell antibodies


thyroglobulin antibodies


microsomal antibodies


antinuclear antibodies


reticulin antibodies


indirect immunofluorescence


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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • R. Lorini
    • 1
  • D. Larizza
    • 1
  • C. Livieri
    • 1
  • V. Cammareri
    • 1
  • A. Martini
    • 1
  • A. Plebani
    • 1
  • D. Zanaboni
    • 1
  • F. Severi
    • 1
  1. 1.Department of Pediatrics, I and II ChairUniversity of PaviaPaviaItaly

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