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European Journal of Pediatrics

, Volume 145, Issue 3, pp 182–184 | Cite as

Auto-immunity in children with diabetes mellitus and in their relatives

  • R. Lorini
  • D. Larizza
  • C. Livieri
  • V. Cammareri
  • A. Martini
  • A. Plebani
  • D. Zanaboni
  • F. Severi
Original Investigations

Abstract

Islet cell antibodies (ICA-IgG and complement-fixing-ICA), parietal cell antibodies (PCA), intestinal epithelial cell antibodies (IECA), thyroglobulin (TgA) and thyroid microsomal antibodies (MsA), antinuclear (ANA) and reticulin antibodics (RA), were studied in 55 insulin-dependent diabetic patients (30 males and 25 females), aged 2–19 years with diabetes from a few days up to 14 years. In 58% of the diabetics one or more autoantibodies were found: ICA-IgG (31%), CF-ICA (16%), PCA (34%), TgA (9%), MsA (9%), ANA (13%), RA (2%). Autoantibodies were significantly more frequent in females (76%) than in males (43%) (P<0.025). ICA-IgG, CF-ICA, PCA, ANA were significantly more frequent in patients than in controls. The frequency of ICA-IgG and CF-ICA was significantly higher during the first 3 years of disease than afterwards (P<0.001); a similar pattern was observed for PCA, TgA, MsA. Of the 87 parents and 30 siblings screened for ICA-IgG, CF-ICA, PCA, IECA, TgA, MsA, ANA and RA, 42 (44%) had one or more autoantibodies, which were more frequent in females than in males. Seven relatives (6%) were ICA-IgG positive (four mothers, two fathers and one brother), and only one mother, ICA-IgG negative, was CF-ICA positive. Other autoantibodies were also more frequent in parents than in controls. Autoantibody-positive relatives have been asymptomatic up to now.

Key words

Type-I diabetes Islet cell antibodies Organ-specific autoimmunity Non-organ-specific autoimmunity 

Abbreviations

ICA

islet cell antibodies

PCA

parietal cell antibodies

IECA

intestinal epithelial cell antibodies

TgA

thyroglobulin antibodies

MsA

microsomal antibodies

ANA

antinuclear antibodies

RA

reticulin antibodies

IF

indirect immunofluorescence

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • R. Lorini
    • 1
  • D. Larizza
    • 1
  • C. Livieri
    • 1
  • V. Cammareri
    • 1
  • A. Martini
    • 1
  • A. Plebani
    • 1
  • D. Zanaboni
    • 1
  • F. Severi
    • 1
  1. 1.Department of Pediatrics, I and II ChairUniversity of PaviaPaviaItaly

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