European Journal of Pediatrics

, Volume 143, Issue 2, pp 135–139 | Cite as

Neuraminidase deficiency presenting as non-immune hydrops fetalis

  • M. Beck
  • S. W. Bender
  • H.-L. Reiter
  • W. Otto
  • R. Bässler
  • H. Dancygier
  • J. Gehler
Original Investigations


A newborn infant with oedema, ascites and hepatosplenomegaly is described. In ascites fluid foamy macrophages were found, in a liver biopsy cytoplasmic inclusions and membrane-bound vacuoles were seen. Furthermore the child excreted excessive amounts of sialic acid-rich oligosaccharides in the urine, and therefore a neurovisceral degenerative disorder was assumed. The diagnosis of sialidosis was confirmed by enzymatic assay in cultured fibroblasts, in which a complete deficiency of the lysosomal enzyme neuraminidase could be demonstrated. After recurrent septicaemias the child became dystrophic and died at the age of 6 months. Our case is compared with sialidoses observed by other authors, the wide phenotypic diversity within this biochemical defect is emphasised. The occurrence of hydrops fetalis in lysosomal storage diseases is discussed.

Key words

Hydrops fetalis Lysosomal storage disease Mucolipidosis I Neuraminidase deficiency 


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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • M. Beck
    • 1
  • S. W. Bender
    • 2
  • H.-L. Reiter
    • 2
  • W. Otto
    • 3
  • R. Bässler
    • 4
  • H. Dancygier
    • 5
  • J. Gehler
    • 1
  1. 1.Kinderklinik der Universität MainzMainzFederal Republic of Germany
  2. 2.Zentrum der KinderheilkundeUniversität FrankfurtFrankfurt/M.Federal Republic of Germany
  3. 3.Kinderklinik der Städtischen Kliniken FuldaFuldaFederal Republic of Germany
  4. 4.Pathologisches Institut der Städt. Kliniken FuldaFuldaFederal Republic of Germany
  5. 5.Zentrum der Inneren MedizinUniversität FrankfurtFrankfurt/M.Federal Republic of Germany

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