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European Journal of Pediatrics

, Volume 143, Issue 2, pp 123–127 | Cite as

Intravenous administration of human IgG to newborn infants: changes in serum antibody levels to group B streptococci

  • K. K. Christensen
  • P. Christensen
  • H. U. Bucher
  • G. Duc
  • C. H. Kind
  • D. Mieth
  • B. Müller
  • R. A. Seger
Original Investigations

Abstract

A human IgG preparation was given intravenously to 36 newborn infants admitted to the neonatal intensive care unit because of suspected septicaemia. IgG was given as a single dose of 0.4 g/kg body weight. Patients serum was obtained immediately before and 30 min after terminating the infusion. Blood was also withdrawn 2 days after giving the IgG in eight of the infants. The sera were tested by radioimmunoassay for IgG antibody levels to surface antigens of group B streptococci (GBS) types Ia, Ib, II and III and to R-protein. The mean increases in anti-type Ia, Ib, II, III and R-protein antibodies 30 min after the end of infusion were 81%, 73%, 49%, 60% and 69% of the preinfusion levels, respectively. This was followed by a rapid decrease during the following 2 days to 25%–32% of the initial increases. Based on the above findings, a controlled trial of passive immunisation in the management of neonatal GBS septicaemia seems justified. The rapid decline in antibody levels would necessitate a second infusion 24 h after the initial immunoglobulin administration if the suspicion of septicaemia persists.

Key words

Streptococci group B Human gammaglobulin Intravenous therapy Neonatal septicaemia 

Abbreviation

GBS

group B streptococci

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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • K. K. Christensen
    • 1
  • P. Christensen
    • 2
  • H. U. Bucher
    • 3
  • G. Duc
    • 3
  • C. H. Kind
    • 3
  • D. Mieth
    • 3
  • B. Müller
    • 3
  • R. A. Seger
    • 3
  1. 1.Department of Obsterics and GynecologyUniversity HospitalLundSweden
  2. 2.Department of Medical MicrobiologyUniversity HospitalLundSweden
  3. 3.Department of Pediatrics, Division of Haematology/Immunology and NeonatologyUniversity of ZürichSwitzerland

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