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Zeitschrift für Kinderheilkunde

, Volume 108, Issue 4, pp 314–324 | Cite as

Plasma-11-Hydroxycorticosteroide bei Müttern, im Nabelschnurblut und bei Neugeborenen in den ersten 5 Lebenstagen

  • E. Pichler
  • U. Lichte
Article
  • 15 Downloads

Zusammenfassung

Mit der leicht modifizierten fluorometrischen Methode von Mattingly wurde der Plasma-11-Hydroxycorticosteroidspiegel von 48 Müttern, 48 dazugehörigen sowie 36 zusätzlichen Nabelschnurbluten und 82 Neugeborenen in den ersten 5 Lebenstagen untersucht. Mütter und Kinder wurden nach Erstund Mehrgeburtlichkeit sowie nach Gruppenzugehörigkeit der Kinder (normal und Dystrophie) aufgeschlüsselt. Unter den Müttern befanden sich 3 Prädiabetikerinnen und 4 Frauen mit Toxämie. 3 Kinder wurden durch Sectio (nicht geplant), die übrigen vaginal geboren.

Der Plasma-11-Hydroxycorticosteroidspiegel erstgebärender Mütter und ihrer Kinder (Nabelschnur) lag durchweg höher als der Mehrgebärender. Dystrophe Kinder und ihre Mütter zeigten höhere Werte als die normale Kontrollgruppe. Bis zur 2. Lebensstunde wurde bei allen (8), bis zur 12. Lebensstunde bei 12 von 32 Kindern ein Ansteigen der Plasma-11-Hydroxycorticosteroide im Vergleich zum Nabelschnurwert gefunden. In den folgenden Lebensstunden kam es zu einem durch-schnittlichen Absinken der Werte (75 von 107 Kindern) mit einem Minimum um die 72. Lebensstunde. Nach der 72. Lebensstunde zeigten vor allem Kinder erstgebärender Mütter eine leicht ansteigende Tendenz. Im Verlauf der ersten 5 Lebenstage konnten keine Unterschiede im Plasma-11-Hydroxycorticosteroidspiegel normaler und dystropher Kinder gefunden werden. Auffallend hohe Werte während der ersten Lebenstage zeigten keine konstante Relation zu Streß-Situationen der Neugeborenen.

The level of plasma steroids shortly after parturition and during the first five days of life

Abstract

By means of the slightly modified fluorometric method by Mattingly plasma-11-hydroxy-corticosteroids were measured in 48 mothers, 84 umbilical cord blood samples, and 82 newborns within their first 5 days of life. Mothers and children were grouped according to parity, and the children were grouped as “normal” and “dystrophic”. 3 mothers were found to have pre-diabetes, 4 were found to have toxemia. All but 3 children (Caesarean sections which had not benn planned) were born vaginally.

Primiparae and their children (cord plasma) had higher plasma steroid levels than multiparae. Distrophic children and their mothers had a higher plasma steroid level than normal children and their mothers.

Compared to the concentration obtained from cord blood plasma the steroid level increased during the first 2 hrs of life in 8 out of 8, up to the age of 12 hrs in 12 out of 32 newborns. 75 out of 107 children showed a decrease of plasmasteroids thereafter; the lowest levels were observed roundabout the 72nd hr of life. After that the plasma steroids showed a rising tendency; this was particularly so in first-born children. During the first 5 days of life no differences were observed in the level of steroids in normal and dystrophic newborns. There was no obvious correlation between high plasma steroid levels and apparent stress during the first 5 days of life.

Key-Words

Plasmasteroids Umbilical Cord Newborn Period Prenatal Dystrophy 

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Copyright information

© Springer-Verlag 1970

Authors and Affiliations

  • E. Pichler
    • 1
  • U. Lichte
    • 1
  1. 1.Universitäts-Kinderklinik WienWienÖsterreich

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