Summary
Vitamin A-deficiency was studied in mice infected with Trypanosoma musculi.
Irrespective of diet, trypomastigotes (trypanosomes) appeared in peripheral tail blood of all inoculated mice after 6-day incubation periods. On the average, vitamin A-deficient mice had parasitemias about 10 times greater than animals fed a complete diet and 8 times pair-fed controls. Parasitemias lasted longer in vitamin-deficient hosts, and reached a maximum five days later than those from control hosts.
The action of the antibody which inhibits reproduction of the trypomastigotes was delayed five days in vitamin-deficient mice; in pair-fed animals ablastic action occurred slightly earlier than in normal control animals. The action of the terminal lytic antibody was delayed by 6 days in metabolically deficient mice than in normal controls and by 4 days in pair-fed controls.
Body weight gains in mice on complete, vitamin A-deficient or pair-fed control diets and given living cells or homogenate of T. musculi showed significant increases over uninoculated controls. Irrespective of dietary group, animals receiving living cells or homogenate of T. musculi ate more food than the control animals beginning 10 days after inoculation. Regardless of diet, no differences in weight gain or food consumption were seen in animals inoculated with physiological saline or metabolic products of T. musculi when compared with uninoculated controls.
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Abbreviations
- N:
-
Averages for uninoculated mice.
- L:
-
Averages for mice inoculated with living cells of T. musculi.
- H:
-
Averages for mice inoculated with homogenate of T. musculi.
- M:
-
Averages for mice inoculated with metabolic products of T. musculi.
- P:
-
Averages for mice inoculated with physiological saline.
References
Ackert, J. E., McIlvaine, M. F., Crawford, N. A.: Resistance of chickens to parasitism affected by vitamin A. Amer. J. Hyg. 13, 320–336 (1931)
Axelrod, A. E., Pruzansky, J.: The role of the vitamins in antibody production. Vitam. and Horm. 13, 1–27 (1955)
Chandler, A. C.: The relation of nutrition to parasitism. J. Egypt. med. Ass. 36, 533–552 (1953)
Chernin, E.: Infection of Australorbis glabratus with Schistosoma mansoni under bacteriologically sterile conditions. Proc. Soc. exp. Biol. (N. Y.) 105, 292–296 (1960)
Lassen, H. C. A.: Experimental studies on the course of parathyphoid infections in avitaminotic rats with special references to vitamin A deficiency. Copenhagen: Levin and Munksgaard 1931
Lawler, M. J.: The relation of vitamin A to immunity to Strongyloides infection. Amer. J. Hyg. 34, 65–72 (1941)
Leuts'kij, K. M.: Theory of the biological activity of vitamin A. Ukrain. biokhim. Zh. 42, 257–264 (1970)
Lincicome, D. R.: Chemical basis of parasitism. Ann. N. Y. Acad. Sci. 113, 360–380 (1963)
Lincicome, D. R., Hill, G. C.: Oxygen uptake by Trypanosoma lewisi-complex cells. I. “L” isolate. Comp. Biochem. Physiol. 14, 425–435 (1965)
Lincicome, D. R., Lee, C. M.: Trypanosoma duttoni: body weight gains, food consumption and longevity of pantothenate-deficient mice given living cells, cell homogenates and cell metabolic products. Exp. Parasit. 30, 331–344 (1971)
Lincicome, D. R., Rossan, R. N., Jones, W. C.: Growth of rats infected with Trypanosoma lewisi. Exp. Parasit. 14, 54–65 (1963)
Lincicome, D. R., Shepperson, J. R.: Experimental evidence for molecular exchanges between a dependent trypanosome cell and its host. Exp. Parasit. 17, 148–167 (1965)
Lincicome, D. R., Watkins, R. C.: Method for preparing pure cell suspensions of Trypanosoma lewisi. Amer. Inst. biol. Sci. Bull. 13, 53–54 (1963)
Ludovici, P. P., Axelrod, A. E.: Circulating antibodies in vitamin-deficiency states. Pteroylglutamic acid, niacintryptophan, vitamins B12, A, and D deficiencies. Proc. Soc. exp. Biol. (N. Y.) 77, 526–530 (1951)
McCoy, O. R.: The effect of vitamin A deficiency on the resistance of rats to infection with Trichinella spiralis. Amer. J. Hyg. 20, 169–180 (1934)
Mueller, J. F.: Parasite-induced weight gain in mice. Ann. N. Y. Acad. Sci. 113, 217–232 (1963)
Olson, J. A.: The metabolism of vitamin A. Pharmacol. Rev. 19, 559–596 (1967)
Pan, C. T.: The course and effect of infection with Schistosoma mansoni in Australorbis glabratus. J. Parasit. 48, 20 (1962)
Taliaferro, W. H.: A reaction product in infections with Trypanosoma lewisi which inhibits the reproduction of the trypanosomes. J. exp. Med. 39, 171–190 (1924)
Taliaferro, W. H.: Ablastic and trypanocidal antibodies against Trypanosoma duttoni. J. Immunol. 35, 303–328 (1938)
Taliaferro, W. H., Taliaferro, L. G.: The resistance of different hosts to experimental infections with special reference to a new method of measuring resistance. Amer. J. Hyg. 2, 264–319 (1932)
Thillet, D. J., Chandler, A. C.: Immunization against Trypanosoma lewisi in rats by injections of metabolic products. Science 125, 346–347 (1957)
Tuft, L.: The effect of reticuloendothelial cell blockage upon antibody formation in rabbits. J. Immunol. 27, 63–80 (1934)
Warsi, A. A.: Metabolic exchange of pyridoxine between a dependent cell and its organic environment. Ph. D. Dissertation, Howard University 1968
Wright, W. H.: The relation of vitamin A deficiency to Ascariasis in the dog. J. Parasit. 21, 433 (1935)
Yaeger, R. G., Miller, O. N.: Effect of malnutrition on susceptibility of rats to Trypanosoma cruzi. V. Vitamin A deficiency. Exp. Parasit. 14, 9–14 (1963)
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Lee, C.M., Aboko-Cole, G.F. & Fletcher, J. Effect of malnutrition on susceptibility of mice to Trypanosoma musculi: Vitamin A-deficiency. Z. F. Parasitenkunde 49, 1–10 (1976). https://doi.org/10.1007/BF00445013
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DOI: https://doi.org/10.1007/BF00445013