Virchows Archiv

, Volume 371, Issue 2, pp 121–129 | Cite as

Abnormal cilia in the bronchial mucosa

Case reports of non-smoking women with bronchogenic carcinomas and an experimental model in guinea-pigs
  • Chikao Torikata
  • Hiroshi Takeuchi
  • Hisao Yamaguchi
  • Keizo Kageyama


Atypical cilia in the bronchial mucosa of non-smoking women and in guinea-pig lungs were studied by the electron microscope. In human cases, numerous compound cilia were observed in the main bronchi. The largest one contained about 40 axial filament complexes in a ciliary shaft. Occasionally, atypical basal bodies were also seen.

In the experimental model in guinea-pigs, 50% oxygen at one atmospheric pressure damaged the bronchial surface and resulted in degeneration and reduction of cilia and pellicular structures. The injury was not sufficiently severe to initiate adaptation and reparative mechanisms in the bronchial mucosa, and rapid renewal of the surface structures was found.

The human cases were associated with bronchogenic carcinoma but the experimental model suggested that atypical cilia were not always related to pulmonary carcinogenesis.

Key words

Compound cilia Axial filament complex Bronchitis Ultrastructure 


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  1. Afzelius, B. A.: Ultrastructure of cilia and flagella. Handbook of Molecular Cytology. North Holland Research Monograph, Chapt. 45, 1119–1145, 1969. Amsterdam-London: North Holland 1969Google Scholar
  2. Ailsby, R. L., Ghadially, F. H.: Atypical cilia in human bronchial mucosa. J. Path. 109, 75–78 (1973)CrossRefPubMedGoogle Scholar
  3. Cordier, A. C.: Ciliogenesis and ciliary anomalies in thymic cysts of “Nude mice”. Cell Tiss. Res. 148, 397–406 (1974)CrossRefGoogle Scholar
  4. Fawcett, D. W., Porter, K. R.: A study of the fine structure of ciliated epithelium. J. Morph. 94, 221–264 (1954)CrossRefGoogle Scholar
  5. Frasca, J. M., Auerbach, O., Parks, V. R.: Electron microscopic observations of the bronchial epithelium of the dogs. II Smoking dogs. Exp. molec. Path. 9, 380–399 (1968)CrossRefPubMedGoogle Scholar
  6. Gaito, R. A., Gaylord, W. H., Hilding, D. A.: Ultrastructure of a human nasal papilloma. Laryngoscope (St. Louis) 75, 144–152 (1965)CrossRefGoogle Scholar
  7. Hando, T., Okada, D. M., Zamboni, L.: Atypical cilia in human endometrium. J. Cell Biol. 39, 475–481 (1968)CrossRefPubMedPubMedCentralGoogle Scholar
  8. Harris, C. C., Kaufman, D. G., Jackson, F., Smith, J. M., Dedick, P., Saffiotti, F.: Atypical cilia in the tracheobronchial epithelium of the hamster during respiratory carcinogenesis. J. Path. 114, 17–21 (1974)CrossRefPubMedGoogle Scholar
  9. Kawabata, I., Paparella, M.: Atypical cilia in normal human and guinea pig middle ear mucosa. Acta oto-laryng. (Stockh.) 67, 511–515 (1969)CrossRefGoogle Scholar
  10. Konradova, V.: Atypical kinocilia in the tracheal epithelium. Folia morph. (Praha) 21, 71–78 (1973)Google Scholar
  11. Luse, S. A., Vietti, T.: Ovarian teratoma. Ultrastructure and neural component. Cancer (Philad.) 21, 38–52 (1968)CrossRefGoogle Scholar
  12. Rhodin, J. A. G.: Ultrastructure and function of the human tracheal mucosa. Amer. Rev. resp. Dis. 93 1–15 (1966)PubMedGoogle Scholar
  13. Satir, P.: On the evolutionary stability of the 9+2 pattern. J. Cell Biol. 12, 181–184 (1962)CrossRefPubMedPubMedCentralGoogle Scholar
  14. Smith, J. Z.: The pathological effects due to increase of oxygen tension in the air breathed. J. Physiol. (Lond.) 24, 19–35 (1899)CrossRefGoogle Scholar
  15. Sorokin, S. P.: Reconstructions of centriole formation and ciliogenesis in mammalian lungs. J. Cell. Sci. 3, 207–230 (1968)PubMedGoogle Scholar
  16. Torikata, C.: Pathological studies on experimental pulmonary fibrosis induced by soluble immune complex—especially on its electron microscopic observations. Acta path. jap. 24, 371–386 (1974)PubMedGoogle Scholar
  17. Trapani, I. L., Garvey, J. S., Campbell, D. H.: Stimulating actions of soluble antigen antibody complexes on normal guinea-pig smooth muscle. Science 127, 700–701 (1958)CrossRefPubMedGoogle Scholar
  18. Watanabe, Y., Kodaira, T., Arimori, M.: Ciliated epithelium in gastric mucosa observed in chronic gastritis. An electon microscopic study. Gann 65, 184 (1974)Google Scholar
  19. Watson, J. H. L., Brinkman, G. L.: Electron microscopy of the epithelial cells of normal and bronchitic human bronchus. Amer. Rev. resp. Dis. 90, 851–866 (1964)PubMedGoogle Scholar
  20. Wong, Y-C., Buck, R. C.: An electron microscopic study of metaplasia of the rat tracheal epithelium in vitamin A deficiency. Lab. Invest. 24, 55–66 (1971)PubMedGoogle Scholar
  21. Yamaguchi, H., Nakajima, S., Torikata, C., Takeuchi, H., Kageyama, K.: Studies on the morphological changes of artery caused by exudation—initial changes of arteritis. Acta path. jap. 22, 441–455 (1972)PubMedGoogle Scholar
  22. Yamaguchi, H., Torikata, C., Takeuchi, H., Kageyama, K.: Morphological changes of the endothelium in the lung with administration of soluble immune complexes. Acta path. jap. 23, 51–58 (1973)PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • Chikao Torikata
    • 1
  • Hiroshi Takeuchi
    • 1
  • Hisao Yamaguchi
    • 1
  • Keizo Kageyama
    • 1
  1. 1.Department of PathologyKeio University, School of MedicineTokyoJapan

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