Abstract
The Mdm-1 gene was mapped to the distal end of Chromosome (Chr) 10. An extensive series of restriction fragment variants was identified among conventional and exotic inbred strains of mice. Mapping was carried out with recombinant inbred strains and an intersubspecific testcross. No recombinants were observed between Mdm-1 and the γ interferon locus (Ifg). These two loci appear to be in linkage disequilibrium among inbred strains. Data from the testcross place Mdm-1 approximately 11 centimorgans distal to the steel (Sl) locus. Because of its extensive polymorphism, Mdm-1 is a useful genetic marker for distal Chr 10.
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Taylor, B.A., Rowe, L. & Grieco, D. Close linkage of Mdm-1, a gene amplified and overexpressed in a transformed 3T3 cell line, with γ interferon (Ifg) on Chromosome 10 of the mouse. Mammalian Genome 3, 700–704 (1992). https://doi.org/10.1007/BF00444365
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DOI: https://doi.org/10.1007/BF00444365