European Journal of Pediatrics

, Volume 128, Issue 3, pp 145–149 | Cite as

Sleep and aminophylline treatment of apnea in preterm infants

  • M. Gabriel
  • C. Witolla
  • M. Albani
Original Investigations


The influence of short-term aminophylline treatment on sleep behaviour was studied in six preterms infants with recurrent apnea. The incidence of apnea, respiratory pauses, and bradycardias which were closely related to the phases of active sleep, decreased during aminophylline treatment. However, the amount of active sleep remained unaffected. The mode of action of aminophylline is discussed in view of the previously proposed neurophysiological concept of apnea of prematurity.

Key words

Active sleep Apnea Aminophylline Preterm infants 


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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • M. Gabriel
    • 1
  • C. Witolla
    • 1
  • M. Albani
    • 1
  1. 1.Department of PediatricsUniversity of GöttingenGöttingenFederal Republic of Germany

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