Abstract
We report a case of a 49-year-old white woman with Gorham-Stout syndrome. This very rare massive osteolysis occurred in the left pelvis and included the femur and the sacral bone. Histology study revealed typical ectatic vessels covered with endothelium. The therapy of choice in this region is radiotherapy with a dose of 40 Gy. However, in our case this therapy only led to short-term pain relief and cessation of the osteolysis. Stabilization with corticospongious bone did not seem to be effective against the progressing osteolysis.
Similar content being viewed by others
References
Abrahams J, Ganick D, Gilbert E, Wolfson J (1980) Massive osteolysis in an infant. Am J Radiol 135:1084–1086
Anavi Y, Sabes WR, Mintz S (1989) Gorham's disease affecting the maxillofacial skeleton. Head Neck 11:550–557
Aston JN (1958) A case of massive osteolysis of the femur. J Bone Joint Surg [Br] 40:514–518
Cannon SR (1986) Massive osteolysis — a review of seven cases. J Bone Joint Surg [Br] 68:24–28
Fornasier VL (1970) Hemangiomatosis with massive osteolysis. J Bone Joint Surg [Br] 52:444–451
Gorham LW, Stout A (1955) Massive osteolysis (acute spontaneous absorption of bone, phantom bone, disappearing bone): its relation to hemangiomatosis. J Bone Joint Surg [Am] 37:985–1004
Gorham LW, Wright AW, Schultz HH, Maxon FC Jr (1954) Disappearing bones: a rare form of massive osteolysis. Report of two cases, one with autopsy findings. Am J Med 17:674–682
Haas JP, Reichelt A (1966) Die isolierte Knochenlymphangiomatose — eine familiäre Erkrankung? Röntgenfortschritte 105:733–755
Halliday DR, Dahlin PC, Pugh DG, Young HH (1969) Massive osteolysis and angiomatosis. Radiology 82:637–644
Harnbach R, Pujman J, Mally V (1958) Massive osteolysis due to haemangiomatosis: report of a case of Gorham's disease with autopsy. Radiology 71:43–47
Handl-Zeller L, Hohenberg G (1990) Radiotherapy of morbus Gorham-Stout: the biological value of low irradiation dose. Br J Radiol 63:206–208
Heyden G, Kindblom LG, Nielsen JM (1977) Diappearing bone disease: A clinical and histological study. J Bone Joint Surg [Am] 59:57–61
Jackson JBS (1838) A singular case of absorption of bone (a boneless arm). Boston Med Surg J 18:368–369
Johnson P, McClure J (1958) Observation on massive osteolysis. Radiology 71:28–41
Jones GB, Midgley RL, Smith GS (1958) Massive osteolysis disappearing bones. J Bone Joint Surg [Br] 40:494–501
Kery L, Wouters HW (1970) Massive osteolysis. Report of two cases. J Bone Joint Surg [Br] 52:452–459
Kessler H, Recht M, Dalinka M (1983) Vascular anomalies in association with osteodystrophies: a spectrum. Skeletal Radiol 10:95–101
King DJ (1946) A case resembling hemangiomatosis of the lower extremity. J Bone Joint Surg [Am] 28:623–628
Kulenkampff HA, Richter GM, Adler CP, Haase WE (1989) Massive Osteolyse (Gorham-Stout-Syndrom) — Klinik, Diagnostik, Therapie und Prognose. Neuere Ergebnisse in der Osteologie. Springer, Berlin Heidelberg New York, pp 387–397
Kulenkampff HA, Richter GM, Haase WE, Adler CP (1990) Massive pelvic osteolysis in the Gorham-Stout syndrome. Int Orthop (SICOT) 14:361–366
Mendez AA, Keret D, Robertson W, MacEwen GD (1989) Massive osteolysis of the femur (Gorham's Disease): a case report and review of the literature. J Pediatr Orthop 9:604–608
Patrick JH (1976) Massive osteolysis complicated by chylothorax successfully treated by pleurodesis. J Bone Joint Surg [Br] 58:347–349
Picault C, Comtet JJ, Imbert C, Boyer JM (1984) Surgical repair of extensive idiopathic osteolysis of the pelvic girdle (Jackson-Gorham disease). J Bone Joint Surg [Br] 66:148–149
Rosenquist CJ, Wolfe DC (1968) Lymphangioma of bone. J Bone Joint Surg [Br] 50:158–163
Schmitt O, Schmitt E, Biehl G (1982) Die essentielle Osteolyse. Klinik und Verlauf eines seltenen Krankheitsbildes. Z Orthop 120:160–164
Tauro B (1992) Multicentric Gorham's disease. J Bone Joint Surg [Br] 74:928–929
Turra ST, Gigante C, Scapinelli R (1990) A 20-year follow-up study of a case of surgically treated massive osteolysis. Clin Orthop 250:297–302
Woodward HR, Chan DP, Lee J (1981) Massive osteolysis of the cervical spine: a case report of bone graft failure. Spine 6:545–549
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Stöve, J., Reichelt, A. Massive osteolysis of the pelvis, femur and sacral bone with a Gorham-Stout syndrome. Arch Orthop Trauma Surg 114, 207–210 (1995). https://doi.org/10.1007/BF00444264
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00444264