European Journal of Pediatrics

, Volume 148, Issue 4, pp 337–340 | Cite as

Reduced urinary serotonin excretion after intake of high doses of hypoxanthine

  • H. Manzke
  • H. Gustmann
Metabolic Diseases

Abstract

Two healthy volunteers were treated with hypoxanthine 3×1 g and allopurinol 3×100 mg daily for 1 week. During this treatment serum oxypurine concentration and urinary oxypurine excretion increased as expected. No side effects were observed except for some mild daytime drowsiness and lethargy. Measurements of urinary serotonin (5-HT) excretion showed decreases to as much as 60% below initial values. Decreased urinary 5-HT excretion was also found in a patient with incomplete Lesch-Nyhan syndrome during treatment with high doses of hypoxanthine. His neurological symptoms improved slightly. The results suggest that high doses of hypoxanthine exert a nonspecific sedative effect on both patients with Lesch-Nyhan syndrome and healthy controls. The cause is probably a reduced synthesis or release of 5-HT.

Key words

Serotonin Hypoxanthine Cortisol Lesch-Nyhan syndrome 

Abbreviations

HGPRT

hypoxanthine-guanine-phosphoribosyltransferase

5-HT

5-hydroxytryptamine (serotonin)

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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • H. Manzke
    • 1
  • H. Gustmann
    • 2
  1. 1.Kinderkrankenhaus Seehospiz “Kaiserin Friedrich”NorderneyFederal Republic of Germany
  2. 2.Universitäts-KinderklinikKielFederal Republic of Germany

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