, Volume 92, Issue 2, pp 115–120 | Cite as

Cyclic adenosine 3′,5′ monophosphate (cAMP) and dimorphism in the pathogenic fungus Paracoccidioides brasiliensis

  • Sophie Paris
  • Silvia Duran


Exogenous cAMP or its analogs inhibit the mycelium transformation of yeast and induce bulging of the apex of mycelia. But intracellular cAMP levels of yeast and mycelial cells are not significantly different.


Adenosine Pathogenic Fungus Monophosphate cAMP Level Intracellular cAMP 
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  1. 1.
    Calich, V. L. G., A. Purchio & C. R. Paula, 1978. A new fluorescentiability test for fungi cells. Mycopathologia 66: 175–177.Google Scholar
  2. 2.
    Carbonell, L. M., 1969. Ultrastructure of dimorphic transformation in Paracoccidioides brasiliensis. J. Bacteriol. 100: 1076–1082.Google Scholar
  3. 3.
    Carbonell, L. M. & F. Gil, 1982. Ultrastructura del Paracoccidioides brasiliensis. In: G. Del Negro, C. da Silva Lacaz & A. Mario Fiorillo (eds), Paracoccidioidomicose blastomicose sul-americana. Sarvier, EDUSP, Saô Paulo, Brasil.Google Scholar
  4. 4.
    Flores-Carreón, A., A. Gómez-Villanueva & F. San-Blas, 1979. ß-1,3-glucanase and dimorphism in Paracoccidioides brasiliensis. Antonie van Leewenhoek 45: 265–274.Google Scholar
  5. 5.
    Garcia, J. R., W. R. Hiatt, J. Peters & P. S. Sypherd, 1980. S-adenosylmethionine levels and protein methylation during morphogenesis of Mucor racemosus. J. Bacteriol. 142: 196–201.Google Scholar
  6. 6.
    Hohman, R. J. & M. Veron, 1984. S-adenosyl-l-homocysteine hydrolase from Dictyostelium discoideum is inactivated by cAMP and reactivated by NAD. FEBS Letters 165: 265–268.Google Scholar
  7. 7.
    Kanetsuna, F., 1981. Ultrastructural studies on the dimorphism of Paracoccidioides brasiliensis, Blastomyces dermatitidis and Histoplasma capsulatum. Sabouraudia 19: 275–286.Google Scholar
  8. 8.
    Kanetsuna, F. & L. M. Carbonell, 1966. Enzymes in glycolysis and the citric acid cycle in the yeast and mycelial forms of Paracoccidioides brasiliensis. J. Bacteriol. 92: 1315–1320.Google Scholar
  9. 9.
    Kanetsuna, F., L. M. Carbonell, I. Azuma & Y. Yamamura, 1972. Biochemical studies on the thermal dimorphism of Paracoccidioides brasiliensis. J. Bacteriol. 110: 208–218.Google Scholar
  10. 10.
    Larsen, A. D. & P. S. Sypherd, 1974. Cyclic adenosine 3′,5′ monophosphate and morphogenesis in Mucor racemosus. J. Bacteriol. 117(2): 432–438.Google Scholar
  11. 11.
    Lowry, O. H., N. J. Rosebrough, A. L. Farr & R. J. Randall, 1951. Protein measurement with the folin phenolreagent. J. Biol. Chem. 193: 265–275.Google Scholar
  12. 12.
    Manocha, M. S., 1980. Lipid composition of Paracoccidioides brasiliensis: comparison between the yeast and mycelial forms. Sabouraudia 18: 281–286.Google Scholar
  13. 13.
    Mardon, D. N., E. Balish & A. W. Phillips, 1969. Control of dimorphism in a biochemical variant of Candida albicans. J. Bacteriol. 100: 701–707.Google Scholar
  14. 14.
    Maresca, B., G. Medoff, D. Schlessinger & G. A. Kobayashi, 1977. Regulation of dimorphism in the pathogenic fungus Histoplasma capsulatum. Nature 266: 447–448.Google Scholar
  15. 15.
    McVeigh, I. & K. Morton, 1965. Nutritional studies of Histoplasma capsulatum. Mycopathologia 25: 294–308.Google Scholar
  16. 16.
    Moreno, R., F. Kanetsuna & L. M. Carbonell, 1969. Isolation of chitin and glucan from the cell walls of the yeast form of Paracoccidioides brasiliensis. Arch. Biochem. Biophys. 130: 212–217.Google Scholar
  17. 17.
    Nickerson, W. J. & G. A. Edwards, 1949. Studies on the physiological bases of morphogenesis in fungi. I. The respiratory metabolism of dimorphic pathogenic fungi. J. Gen. Physiol. 33: 41–55.Google Scholar
  18. 18.
    Niimi, M. & K. Niimi, 1980. Changes in cyclic nucleotide levels and dimorphic transition in Candida albicans. J. Bacteriol. 142: 1010–1014.Google Scholar
  19. 19.
    Pall, M. L., 1981. Adenosine 3′,5′-phosphate in fungi. Microbiological Rev. 45: 462–480.Google Scholar
  20. 20.
    Paris, S., S. Duran & F. Mariat, 1985. Nutritional studies on Paracoccidioides brasiliensis: the role of organic sulfur in dimorphism. Sabouraudia (submitted for publication).Google Scholar
  21. 21.
    Paris, S. & R. G. Garrison, 1984. Cyclic adenosine — 3′,5′-monophosphate (cAMP) as a factor in phase morphogenesis of Blastomyces dermatitidis. Mykosen 27: 340–345.Google Scholar
  22. 22.
    Ramirez-Martinez, J. R., 1971. A comparative study of ribonucleic acid species in yeastlike and mycelial forms of Paracoccidioides brasiliensis. Sabouraudia 9: 157–163.Google Scholar
  23. 23.
    Restrepo, A. & B. E. Jimenez, 1980. Growth of Paracoccidioides brasiliensis yeast phase in a chemically defined culture medium. J. Clin. Microbiol. 12: 279–281.Google Scholar
  24. 24.
    Rodriguez del Valle, N., N. Debselias & A. Alsina, 1984. Effects of caffeine, cyclic 3′,5′ adenosine monophosphate and cyclic 3′,5′ guanosine monophosphate in the development of the mycelial form of Sporothrix schenckii. Mycopathologia 86: 29–33.Google Scholar
  25. 25.
    San-Blas, G. & F. San-Blas, 1984. Molecular aspects of fungal dimorphism. C.R.C. Critical Reviews in Microbiology. 11: 101–127.Google Scholar
  26. 26.
    San-Blas, F., G. San-Blas, J. Hallak & E. Merino, 1983. Ultrastructure and cell wall chemistry of a thermosensitive mutant of Paracoccidioides brasiliensis. Current Microbiology 8: 85–88.Google Scholar
  27. 27.
    San-Blas, F., G. San-Blas & D. Inlow, 1980. Dimorphism in Paracoccidioides brasiliensis. In: Medical mycology, Zentralbl. Bakteriol. Hyg. Suppl. 8. J. H. Preusser-Gustav Fischer Verlag, Stuttgart, New-York, pp. 23–28.Google Scholar
  28. 28.
    San-Blas, F., G. San-Blas & L. Yarzabal, 1981. A mycelial mutant of Paracoccidioides brasiliensis defective in dimorphism: chemical and immunological characterization. Experimental Mycology 5: 23–34.Google Scholar
  29. 29.
    Steiner, A. L., 1974. Assay of cyclic nucleotides by radioimmunoassay methods. In: J. G. Hardman & B. W. O'Molley (eds), Methods in enzymology, vol. 38. Acad. Press, NY, pp. 96–105.Google Scholar
  30. 30.
    Szaniszlo, P. J., C. W. Jacob & P. A. Geis, 1983. Dimorphism: morphological and biochemical aspects. In: Dexter H. Howard (ed.), Fungi pathogenic for humans and animals, Part A, Biology. Marcel Dekker inc., pp. 323–436.Google Scholar

Copyright information

© Martinus Nijhoff/Dr W. Junk Publishers 1985

Authors and Affiliations

  • Sophie Paris
    • 1
  • Silvia Duran
    • 1
  1. 1.Unité de MycologieInstitut PasteurParis Cedex 15France

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