Summary
Two patients with malignant insulinoma and hepatic metastases were treated with streptozotocin, administered directly into the celiac artery. Decreases in tumor size were documented radiographically. One patient was in a terminal state when first treated, but the other patient was in moderately good general health and responded well. Some side-effects, including renal tubular damage, were observed but were relatively minor. Streptozotocin therapy offers some benefit in patients with malignant insulinoma.
Résumé
Deux patients atteints d'insulinome avec métastases hépatiques ont été traités par injection de streptozotocine dans l'artère coeliaque. Une diminution des dimensions de la tumeur a été mise en évidence radiologiquement. L' un des patients était dans un état terminal au moment où le traitement a été institué; l'autre patient dont l'état général était relativement bon a bien répondu à la thérapeutique. Certains effets collatéraux dont des signes d'atteinte rénale tabulaire, ont été notés mais sont relativement peu importants. La streptozotocine offre donc un certain interêt dans le traitement de l'insulinome malin.
Zusammenfassung
Zwei Patienten mit metastasierendem Insulinom wurde Streptozotozin in die Arteria coeliaca verabreicht. Daraufhin ließ sich radiographisch ein Rückgang der Tumorgröße nachweisen. Bei Therapiebeginn befand sich ein Patient in mäßigem, der andere in sehr schlechtem Allgemeinzustand. Einige Nebenwirkungen, insbesondere Schädigung der Nierentubuli, traten auf, waren aber von geringem Ausmaß. Streptozotozin ist geeignet, Patienten, die an einem malignen Insulinom leiden, Linderung zu verschaffen.
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Supported by grants (AM 05020 and AM 02456) from the United States Public Health Service. A portion of this work was conducted through the Clinical Research Center of the University of Washington supported by the NIH (Grant RR-37). (Dr. Stoll is the recipient of Special Fellowship 5 F3 AM 37, 832).
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Smith, C.K., Stoll, R.W., Vance, J. et al. Treatment of malignant insulinoma with streptozotocin. Diabetologia 7, 118–124 (1971). https://doi.org/10.1007/BF00443892
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DOI: https://doi.org/10.1007/BF00443892