Zeitschrift für Kinderheilkunde

, Volume 117, Issue 3, pp 233–240 | Cite as

Growth hormone secretion in diabetic children

  • Ewa Otto-Buczkowska
  • Franciszek Kokot
  • Jadwiga Kuska


The postinsulin secretion pattern of the human growth hormone (HGH) was examined in 14 healthy and 27 diabetic children. Significantly higher HGH levels were found in diabetic than in healthy subjects before insulin injection as well as in the early phase of the test. This abnormality in HGH secretion increased with the duration of diabetes. No sex-related differences in HGH secretion were found in healthy or diabetic children.

Key words

Diabetes Human growth hormone Postinsulin hypoglycemia 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Baker, L., Kaye, R., Root, A. W.: The early partial remission of juvenile diabetes mellitus. The roles of insulin and growth hormone. J. Pediat. 71, 825 (1967)Google Scholar
  2. 2.
    Beaumont, P., Schofield, P. J., Hollows, F. C., Williams, J. F., Steinbeck, A. W.: Growth hormone, sorbital and diabetic capillary disease. Lancet 1971 I, 579Google Scholar
  3. 3.
    Boshell, B. R., Chaudalia, H. B.: Hormonal interrelationships. In: Diabetes mellitus: Theory and practice, Ellenberg, M., Rifkin, H., Eds., p. 96. New York: Mc Graw-Hill 1970Google Scholar
  4. 4.
    Czyżyk, A.: Cukrzyca. In: Endokrynologia kliniczna, Hartwig, W., Ed., p. 875. Warszawa: PZWL 1972Google Scholar
  5. 5.
    Drash, A., Field, J. B., Graces, L. Y., Kenny, F. M., Mintz, D., Vazquez, A. M.: Endogenous insulin and growth hormone response in children with newly diagnosed diabetes mellitus. Pediat. Res. 2, 94 (1968)Google Scholar
  6. 6.
    Fatourechi, V., Molnar, G. D., Service, F. J., Ackerman, E., Rosevear, J. W., Moxnass, K. E., Taylor, W. F.: Growth hormone and glucose interrelationships in diabetes: Studies with insulin infusion during continous blood glucose analysis. J. clin. Endocr. 29, 319 (1969)Google Scholar
  7. 7.
    Glick, S. M., Roth, J., Yalow, R. W., Berson, S. A.: The regulation of growth hormone secretion. Recent Progr. Hormone Res. 21, 251 (1965)Google Scholar
  8. 8.
    Hansen, Aa. P., Johansen, K.: Diurnal patterns of blood glucose, serum free fatty acids, insulin, glucagon and growth hormone in normals and juvenile diabetics. Diabetologia 6, 27 (1970)Google Scholar
  9. 9.
    Hansen, Aa. P.: Abnormal serum growth hormone response to exercise in juvenile diabetics. J. clin. Invest. 49, 1467 (1970)Google Scholar
  10. 10.
    Hansen, Aa. P.: The effect of adrenergic receptor blockade on the exerciseinduced serum growth hormone rise in normals and juvenile diabetics. J. clin. Endocr. 33, 807 (1971)Google Scholar
  11. 11.
    Hansen, Aa. P.: Serum growth hormone patterns in female juvenile diabetics. J. Endocr. Metab. 36, 638 (1973)Google Scholar
  12. 12.
    Hywarinen, A., Nikkila, B. A.: Specific determination of blood glucose with o-toluidine. Clin. chim. Acta 7, 140 (1962)Google Scholar
  13. 13.
    Johansen, K., Hansen, Aa. P.: High 24-hour level of serum growth hormone in juvenile diabetics. Brit. med. J. 1969 II, 356Google Scholar
  14. 14.
    Johansen, K., Hansen, Aa. P.: Diurnal serum growth hormone levels in poorly and well-controlled juvenile diabetics. Diabetics. 20, 239 (1971)Google Scholar
  15. 15.
    Kosowicz, J., Psujowa, Z., Fajfrowski, T., Matecka, Z.: Steżenie ludzkiego hormonu wzrostu w cukrzycy po obciażeniu glukoza. Pol. Arch. Med. wewnet. 49, 261 (1972)Google Scholar
  16. 16.
    Kosowicz, J.: Radioimmunologiczne oznaczanie hormonu wzrostu i jego znaczenie kliniczne. Pol. Arch. Med. wewnet. 49, 305 (1972)Google Scholar
  17. 17.
    Lenti, G., Frezzotti, R., Angotzi, G., Bardelli, A. M., Pagano, G.: Growth hormone plasma levels in normal subjects and diabetics with and without retinopathy, during glucose and insulin administration. European Association for the Study of Diabetes. Abstracts of the 8th Annual Meeting, Madrid 1972, position 164Google Scholar
  18. 18.
    Levine, R., Luft, R.: The relation between the growth and diabetogenic effects of the so-called growth hormone of the anterior pituitary. Diabetes 13, 651 (1964)Google Scholar
  19. 19.
    Lipman, R. L., Taylor, A. L., Conly, P., Mintz, D. H.: Metabolic clearance rate of growth hormone in juvenile diabetes mellitus. Diabetes 21, 175 (1972)Google Scholar
  20. 20.
    Lundbaek, K., Jensen, V. A., Olsen, T. S., Örskov, H., Christensen, N. J., Johansen, K., Hansen, Aa. P., Österby, R.: Diabetes, diabetic angiopathy and growth hormone. Lancet 1970 II, 131Google Scholar
  21. 21.
    Mahler, R. J., Zzabo, O.: Early insulin synergistic activity of growth hormone. Diabetes 18, 550 (1969)Google Scholar
  22. 22.
    Parker, M. L., Pildes, R. S., Chao, K. L., Cornblath, M., Kipnis, D. A.: Juvenile diabetes mellitus a deficiency in insulin. Diabetes 17, 27 (1968)Google Scholar
  23. 23.
    Parker, D., Rossman, L. G.: Sleep release of human growth hormone in treated juvenile diabetics. Diabetes 20, 691 (1971)Google Scholar
  24. 24.
    Root, A. W., Rosenfield, R. L., Poggiovanni, A. W., Eberlein, W. R.: The plasma growth hormone response to insulin-induced hypoglycemia in children with retardation of growth. Pediatrics 39, 844 (1967)Google Scholar
  25. 25.
    Sönksen, P. H., Greenwood, F. C., Ellis, J. P., Lowy, C., Rutherford, A., Nabarro, J. D. N.: Changes of carbohydrate tolerance in acromegaly with progress of disease and in response to treatment. J. clin. Endocr. 27, 1418 (1967)Google Scholar
  26. 26.
    Stauffacher, W., Renold, A. E.: Pathophysiology of diabetes mellitus. In: Joslin's diabetes mellitus, Marble, A., White, P., Bradley, R. F., Krall, L. P., Eds., p. 35. Philadelphia: Lea and Febiger 1971Google Scholar
  27. 27.
    Tatoń, J.: Diabetologia kliniczna. Warszawa: PZWL 1971Google Scholar
  28. 28.
    Theodoridis, C. G., Chance, G. W., Brown, G. A., Williams, J. W.: Plasma insulin and growth hormone levels in untreated diabetic children. Arch. Dis. Child. 45, 70 (1970)Google Scholar
  29. 29.
    Theodoridis, C. G., Chance, G. W., Rudd, B. T.: Fasting growth hormone in treated diabetic children. Arch. Dis. Child. 45, 720 (1970)Google Scholar
  30. 30.
    Westphal, O.: Human growth hormone. A methodological and clinical study. Acta pediat. scand., Suppl. 182 (1968)Google Scholar
  31. 31.
    Yde, H.: Abnormal growth hormone response to ingestion of glucose in juvenile diabetic. Acta med. scand. 186, 499 (1969)Google Scholar
  32. 32.
    Yde, H.: The immunoreactive growth hormone in serum from patients with various types of diabetes mellitus. Acta endocr. 64, 339 (1970)Google Scholar

Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • Ewa Otto-Buczkowska
    • 1
  • Franciszek Kokot
    • 2
  • Jadwiga Kuska
    • 2
  1. 1.District Polyclinic for Diabetic Children in ZabrzeZabrzePoland
  2. 2.2nd Medical ClinicSilesian School of MedicineKatowice

Personalised recommendations